An "in control" hyaluronic acid nanogel with light-cleavable for rational use of antibiotics

被引：0

作者：

Sun, Feifei ^{[1
,2
,3
]}

Xiao, Yao ^{[3
]}

Kong, Lili ^{[3
]}

Mu, Haibo ^{[3
]}

Wang, Xing ^{[3
]}

Duan, Jinyou ^{[3
]}

机构：

[1] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China

[2] Univ Chinese Acad Sci, Shenyang, Peoples R China

[3] Northwest A&F Univ, Coll Chem & Pharm, Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Shaanxi, Peoples R China

来源：

HELIYON | 2024年 / 10卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Hyaluronic acid; Nanogels; Light-responsive; Ciprofloxacin; Bacterial infection; CROSS-LINKING; DELIVERY; DERIVATIVES; MICELLES;

D O I：

10.1016/j.heliyon.2024.e33287

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The consequences caused by bacterial resistance are becoming more and more serious. The rate of antibiotic development is far behind the rate of bacterial resistance, so it is urgent to develop a new drug system. In this study, photoresponsive nanogels based on hyaluronic acid were prepared and loaded with ciprofloxacin as a model molecule. The results showed that the nanogels had the advantages of high stability and good cytocompatibility. The inhibition effect of drug-loaded nanogels after light irradiation on the growth of Staphylococcus aureus and Salmonella typhimurium was significantly better than that before light irradiation, and ciprofloxacin could be released on demand and in control. This strategy is of great significance to reduce the unnecessary use of antibiotics and weaken bacterial resistance.

引用

页数：12

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