The Role of Inflammasome in Abdominal Aortic Aneurysm and Its Potential Drugs

被引：9

作者：

Pi, Suyu ^{[1
,2
]}

Xiong, Sizheng ^{[1
,2
]}

Yuan, Yan ^{[1
,2
]}

Deng, Hongping ^{[1
,2
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Vasc Surg, Wuhan 430060, Peoples R China

[2] Aort Abdominal Aneurysm AAA Translat Med Res Ctr H, Wuhan 430060, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 09期

关键词：

abdominal aortic aneurysm; inflammasome; NLRP3; AIM2; inflammation; activation and regulation; potential drugs; REGULATES NLRP3 INFLAMMASOME; MELANOMA; 2; INCREASED EXPRESSION; ACTIVATION; AIM2; INTERLEUKIN-1-BETA; ATHEROSCLEROSIS; PROGRESSION; CASPASE-1; FAMILY;

D O I：

10.3390/ijms25095001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abdominal aortic aneurysm (AAA) has been recognized as a serious chronic inflammatory degenerative aortic disease in recent years. At present, there is no other effective intervention except surgical treatment for AAA. With the aging of the human population, its incidence is increasing year by year, posing a serious threat to human health. Modern studies suggest that vascular chronic inflammatory response is the core process in AAA occurrence and development. Inflammasome, a multiprotein complex located in the cytoplasm, mediates the expression of various inflammatory cytokines like interleukin (IL)-1 beta and IL-18, and thus plays a pivotal role in inflammation regulation. Therefore, inflammasome may exert a crucial influence on the progression of AAA. This article reviews some mechanism studies to investigate the role of inflammasome in AAA and then summarizes several potential drugs targeting inflammasome for the treatment of AAA, aiming to provide new ideas for the clinical prevention and treatment of AAA beyond surgical methods.

引用

页数：17

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