Impact of oral administration of calcitriol to prevent symptomatic hypocalcemia after total thyroidectomy: Systematic review and meta-analysis

被引：0

作者：

Dadkhah, Parisa A. ^{[1
]}

Farshid, Amirali ^{[2
]}

Khademi, Reza ^{[3
]}

Yaghoubi, Shayan ^{[4
]}

Asadzadeh, Ailin ^{[5
]}

Moharamnejad, Nima ^{[2
]}

Jadidian, Faezeh ^{[6
]}

Ziaei, Seyed A. ^{[7
]}

Haghshoar, Sepehr ^{[8
]}

Salimi, Omid ^{[9
]}

Shafagh, Seyyed-Ghavam ^{[10
]}

Rabiei, Negin ^{[11
]}

Shahsavari, Saleh ^{[12
]}

Shokravi, Samin ^{[13
]}

Maroufi, Zahra ^{[14
]}

Deravi, Niloofar ^{[15
]}

Erabi, Gisou ^{[16
]}

Naziri, Mahdyieh ^{[17
]}

机构：

[1] Isfahan Univ Med Sci, Student Res Comm, Sch Med, Esfahan, Iran

[2] Ardabil Univ Med Sci, Student Res Comm, Fac Med, Ardebil, Iran

[3] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[4] Islamic Azad Univ Ardabil, Fac Med, Ardebil, Iran

[5] Ardabil Univ Med Sci, Student Res Comm, Sch Pharm, Ardebil, Iran

[6] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran

[7] Fasa Univ Med Sci, Student Res Comm, Fasa, Fars, Iran

[8] Cyprus Int Univ, Fac Pharm, Nicosia, Cyprus

[9] Islamic Azad Univ Najafabad, Student Res Comm, Fac Med, Esfahan, Iran

[10] Iran Univ Med Sci IUMS, Fac Med, Tehran, Iran

[11] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran

[12] Shahid Beheshti Univ Med Sci, Shohadaye Tajrish Hosp, Dept Surg, Tehran, Iran

[13] Larkin Community Hosp, Dept Res & Acad Affairs, Miami, FL USA

[14] Shahid Sadoughi Univ Med Sci, Sch Med, Student Res Comm, Yazd, Iran

[15] Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Med, Tehran, Iran

[16] Urmia Univ Med Sci, Student Res Comm, Resaalat Ave, Orumiyeh 5714783734, Iran

[17] Iran Univ Med Sci IUMS, Student Res Comm, Sch Med, Shahid Hemmat Highway, Tehran 14496, Iran

来源：

SCANDINAVIAN JOURNAL OF SURGERY | 2024年 / 113卷 / 04期

关键词：

Calcitriol; hypocalcaemia; thyroidectomy; parathyroid hormone; vitamin D; PARATHYROID-HORMONE ASSAY; VITAMIN-D SUPPLEMENTS; POSTOPERATIVE HYPOCALCEMIA; EARLY PREDICTION; CALCIUM LEVELS; RISK-FACTORS; SURGERY; HYPOPARATHYROIDISM;

D O I：

10.1177/14574969241251899

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: One of the most common complications of total thyroidectomy is post-operative transient or persistent hypoparathyroidism that can cause symptomatic hypocalcaemia. To prevent this complication, shorten the period of hospitalization and reduce morbidity, routine supplementation of oral vitamin D and calcium has been suggested. This systematic review and meta-analysis aims to critically assess the association between pre-operative calcitriol supplementation and post-operative hypocalcaemia.Methods: Randomized controlled trial studies were identified by searching PubMed, Scopus, and Google Scholar databases up to 30 March 2023. Screening of titles, abstracts, and full texts of articles were performed, and data were extracted for a meta-analysis.Results: This meta-analysis includes data from nine randomized controlled trials with a total of 1259 patients but with significant heterogeneity. The results demonstrate that calcium levels were higher in patients who had pre-operative calcitriol supplementation, with a weighted mean difference (WMD) 0.18 (95% confidence interval (CI) = 0.00, 0.37). Pre-operative calcitriol supplementation did not lead to significant changes in parathyroid hormone (PTH) levels, with WMD -0.49 (95% CI: -1.91, 0.94).Conclusion: Pre-operative calcitriol supplementation leads to higher calcium levels, but the high heterogeneity of the included studies (79% to 98.7%) could affect the results.

引用

页码：263 / 272

页数：10

共 49 条

[1] Is There a Minimum Number of Thyroidectomies a Surgeon Should Perform to Optimize Patient Outcomes? [J].