Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases

被引:0
作者
Wu, Qi [1 ]
Yao, Jiangting [1 ]
Xiao, Mengyun [1 ]
Zhang, Xiawei [1 ]
Zhang, Mengxiao [2 ]
Xi, Xinting [1 ]
机构
[1] Bengbu Med Univ, Sch Med Imaging, Bengbu, Peoples R China
[2] Bengbu Med Univ, Sch Pharm, Bengbu, Peoples R China
基金
中国国家自然科学基金;
关键词
Nuclear factor erythroid 2-related factor 2 (Nrf2); cardiovascular diseases (CVDs); oxidative stress (OS); therapeutic strategy; Nrf2; activators; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; HEART-FAILURE; HYPERTENSION; MICE; PATHOPHYSIOLOGY; SUPPRESSES; ACTIVATION; EXPRESSION; APOPTOSIS;
D O I
10.1080/1061186X.2024.2356736
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cardiovascular diseases (CVDs) are the leading cause of death globally, with oxidative stress (OS) identified as a primary contributor to their onset and progression. Given the elevated incidence and mortality rates associated with CVDs, there is an imperative need to investigate novel therapeutic strategies. Nuclear factor erythroid 2-related factor 2 (Nrf2), ubiquitously expressed in the cardiovascular system, has emerged as a promising therapeutic target for CVDs due to its role in regulating OS and inflammation. This review aims to delve into the mechanisms and actions of the Nrf2 pathway, highlighting its potential in mitigating the pathogenesis of CVDs.
引用
收藏
页码:874 / 883
页数:10
相关论文
共 116 条
[11]   Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway [J].
Chen, Xiuhuan ;
Wan, Weiguo ;
Guo, Yan ;
Ye, Tianxin ;
Fo, Yuhong ;
Sun, Yazhou ;
Qu, Chuan ;
Yang, Bo ;
Zhang, Cui .
MOLECULAR MEDICINE, 2021, 27 (01)
[12]   Treatment of Stress Urinary Incontinence by Cinnamaldehyde, the Major Constituent of the Chinese Medicinal Herb Ramulus Cinnamomi [J].
Chen, Yung-Hsiang ;
Lin, Yu-Ning ;
Chen, Wen-Chi ;
Hsieh, Wen-Tsong ;
Chen, Huey-Yi .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014, 2014
[13]   Sestrin2 as a Potential Target in Hypertension [J].
Didik, Steven ;
Wang, Hao ;
James, Adewale Segun ;
Slotabec, Lily ;
Li, Ji .
DIAGNOSTICS, 2023, 13 (14)
[14]   Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: Role of Nrf2 activation [J].
Ding, Yi ;
Zhang, Bin ;
Zhou, KaiYuan ;
Chen, MinChun ;
Wang, MingMing ;
Jia, YanYan ;
Song, Ying ;
Li, YuWen ;
Wen, AiDong .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2014, 175 (03) :508-514
[15]   Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice [J].
Farooqui, Zeba ;
Mohammad, Razia Sultana ;
Lokhandwala, Mustafa F. ;
Banday, Anees Ahmad .
CLINICAL AND EXPERIMENTAL HYPERTENSION, 2021, 43 (02) :175-180
[16]  
Frangogiannis NG, 2015, COMPR PHYSIOL, V5, P1841, DOI 10.1002/cphy.c150006
[17]   Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy [J].
Ge, Zhi-Dong ;
Lian, Qingquan ;
Mao, Xiaowen ;
Xia, Zhengyuan .
INTERNATIONAL HEART JOURNAL, 2019, 60 (03) :512-520
[18]   Worsening Heart Failure: Nomenclature, Epidemiology, and Future Directions JACC Review Topic of the Week [J].
Greene, Stephen J. ;
Bauersachs, Johann ;
Brugts, Jasper J. ;
Ezekowitz, Justin A. ;
Lam, Carolyn S. P. ;
Lund, Lars H. ;
Ponikowski, Piotr ;
Voors, Adriaan A. ;
Zannad, Faiez ;
Zieroth, Shelley ;
Butler, Javed .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2023, 81 (04) :413-424
[19]   Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association [J].
Griendling, Kathy K. ;
Touyz, Rhian M. ;
Zweier, Jay L. ;
Dikalov, Sergey ;
Chilian, William ;
Chen, Yeong-Renn ;
Harrison, David G. ;
Bhatnagar, Aruni .
CIRCULATION RESEARCH, 2016, 119 (05) :E39-E75
[20]   Tanshinone IIA protects H9c2 cells from oxidative stress-induced cell death via microRNA-133 upregulation and Akt activation [J].
Gu, Yunfei ;
Liang, Zhuo ;
Wang, Haijun ;
Jin, Jun ;
Zhang, Shouyan ;
Xue, Shufeng ;
Chen, Jianfeng ;
He, Huijuan ;
Duan, Kadan ;
Wang, Jing ;
Chang, Xuewei ;
Qiu, Chunguang .
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 12 (02) :1147-1152