Terpenoids derived from Semen Ziziphi Spinosae oil enhance sleep by modulating neurotransmitter signaling in mice

被引：3
作者：
Sun, Mingzhe [1 ,2 ]
Li, Mengnan [3 ,4 ]
Cui, Xinwen [1 ]
Yan, Lin [2 ]
Pei, Yiqiao [5 ]
Wang, Chao [2 ]
Guan, Chunbo [1 ]
Zhang, Xiuqing [1 ]
机构：
[1] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
[2] Hlth Foods R&D Off Hebei Yiling Pharmaceut Res Ins, Shijiazhuang 050035, Peoples R China
[3] Natl Key Lab Innovat & Transformat Luobing Theory, Shijiazhuang 050035, Peoples R China
[4] Key Lab State Adm TCM Cardiocerebral Vessel Collat, Shijiazhuang 050035, Peoples R China
[5] Tianjin Univ Sci & Technol, Coll Food Engn & Biotechnol, Tianjin 300457, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 05期
基金：
中国博士后科学基金;
关键词：
Natural products; Sleep-promoting; Terpenoids; Neurotransmitter; Anti-oxidative; PENTOBARBITAL-INDUCED SLEEP; RAT INTESTINAL FLORA; DEGRADATION KINETICS; CLOCK GENES; JUJUBOSIDE; RECEPTORS; GABA(A); SEEDS; PHARMACOLOGY; ELUCIDATION;
D O I：
10.1016/j.heliyon.2024.e26979
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Semen Ziziphi Spinosae oil (SZSO) is a natural vegetable oil extracted from Semen Ziziphi Spinosae, a traditional Chinese medicine renowned for its sleep-promoting properties, while the mechanisms are still unclear. Our findings revealed that the terpenoids present in SZSO (T-SZSO) were identified as the active components responsible for promoting sleep. Network pharmacological analysis suggested that T-SZSO targeted different sleep-aid pathways to varying degrees and exhibited potential for preventing central nervous system diseases. Notably, lupeol and betulinicaldehyde exhibited more pronounced effects. Additionally, T-SZSO significantly elevated serotonin levels, enhanced gamma-aminobutyric acid (GABA) synthesis, promoted GABA A receptor expression, and decreased glutamate and norepinephrine expression levels. Moreover, TSZSO was found to downregulate IL-1 beta expression while upregulating superoxide dismutase and inducible nitric oxide synthase levels. In conclusion, this study presents the first investigation into the pharmacological basis of SZSO in promoting sleep and highlights the potential of nature food in improving suboptimal health conditions.
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页数：15
相关论文
共 82 条
[81]  
[周永红 Zhou yonghong], 2005, [中国油脂, China Oils and Fats], V30, P68
[82]  
Zuo JP, 2011, ROCK SOIL MECH, V32, P1287
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