Regulation and functions of membrane lipids: Insights from Caenorhabditis elegans

被引：10

作者：

Koyiloth, Muhasin ^{[1
]}

Gummadi, Sathyanarayana N. ^{[1
]}

机构：

[1] Indian Inst Technol Madras, Bhupat & Jyoti Mehta Sch Biosci, Dept Biotechnol, Appl & Ind Microbiol Lab, Chennai 600036, India

来源：

BBA ADVANCES | 2022年 / 2卷

关键词：

Membrane lipid biogenesis; Membrane lipid homeostasis; Membrane fluidity; Lipid transport; C. elegans as disease model; UNFOLDED PROTEIN RESPONSE; C; ELEGANS; LIFE-SPAN; AUTOPHAGY GENES; ER STRESS; METABOLISM; PHOSPHOLIPIDS; MODEL; DISEASE; RESISTANCE;

D O I：

10.1016/j.bbadva.2022.100043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Caenorhabditis elegans plasma membrane is composed of glycerophospholipids and sphingolipids with a small cholesterol. The C. elegans obtain the majority of the membrane lipids by modifying fatty acids present in the bacterial diet. The metabolic pathways of membrane lipid biosynthesis are well conserved across the animal kingdom. In C. elegans CDP-DAG and Kennedy pathway produce glycerophospholipids. Meanwhile, the sphingolipids are synthesized through a different pathway. They have evolved remarkably diverse mechanisms to maintain membrane lipid homeostasis. For instance, the lipid bilayer stress operates to accomplish homeostasis during any perturbance in the lipid composition. Meanwhile, the PAQR-2/IGLR-2 complex works with FLD-1 to balance unsaturated to saturated fatty acids to maintain membrane fluidity. The loss of membrane lipid homeostasis is observed in many human genetic and metabolic disorders. Since C. elegans conserved such genes and pathways, it can be used as a model organism.

引用

页数：11

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