Environmental Determinants of Islet Autoimmunity (ENDIA) longitudinal prospective pregnancy to childhood cohort study of Australian children at risk of type 1 diabetes: parental demographics and birth information

被引：0

作者：

Thomson, Rebecca L. ^{[1
,2
]}

Oakey, Helena ^{[1
,2
]}

Haynes, Aveni ^{[3
]}

Craig, Maria E. ^{[4
,5
]}

Harrison, Leonard C. ^{[6
,7
]}

Wentworth, John M. ^{[6
,8
]}

Anderson, Amanda ^{[1
,2
]}

Ashwood, Pat ^{[1
,2
]}

Barry, Simon ^{[1
,2
]}

Brittain, Bek ^{[9
]}

Brown, James D. ^{[1
,2
]}

Colman, Peter G. ^{[8
]}

Davis, Elizabeth A. ^{[3
]}

Hamilton-Williams, Emma ^{[10
]}

Huynh, Dao ^{[1
,2
]}

Huynh, Tony ^{[11
,12
]}

Kim, Ki-Wook ^{[5
,13
]}

McGorm, Kelly J. ^{[1
,2
]}

Morahan, Grant ^{[9
]}

Rawlinson, William ^{[5
,13
]}

Sinnott, Richard O. ^{[14
]}

Soldatos, Georgia ^{[15
,16
,17
]}

Tye-Din, Jason A. ^{[6
]}

Vuillermin, Peter J. ^{[18
,19
]}

Penno, Megan A. S. ^{[1
,2
]}

Couper, Jennifer J. ^{[1
,2
,20
]}

机构：

[1] Univ Adelaide, Fac Hlth & Med Sci, Adelaide Med Sch, Adelaide, SA, Australia

[2] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia

[3] Univ Western Australia, Telethon Kids Inst, Ctr Child Hlth Res, Nedlands, WA, Australia

[4] Childrens Hosp Westmead, Inst Endocrinol & Diabet, Westmead, NSW, Australia

[5] Univ New South Wales, Fac Med & Hlth, Sch Clin Med, Discipline Paediat & Child Hlth, Sydney, NSW, Australia

[6] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia

[7] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia

[8] Royal Melbourne Hosp, Dept Diabet & Endocrinol, Parkville, Vic, Australia

[9] Univ Western Australia, Harry Perkins Inst Med Res, Ctr Diabet Res, Perth, WA, Australia

[10] Univ Queensland, Frazer Inst, Brisbane, Qld, Australia

[11] Queensland Childrens Hosp, Dept Endocrinol & Diabet, South Brisbane, Qld, Australia

[12] Univ Queensland, Childrens Hlth Res Ctr, Brisbane, Qld, Australia

[13] Prince Wales Hosp, Serol & Virol Div SaViD, New South Wales Hlth Pathol, Sydney, NSW, Australia

[14] Univ Melbourne, Sch Comp & Informat Serv, Melbourne Eres Grp, Melbourne, Vic, Australia

[15] Monash Univ, Fac Med Nursing & Hlth Sci, Sch Publ Hlth & Prevent Med, Clayton, Vic, Australia

[16] Monash Univ, Fac Med Nursing & Hlth Sci, Sch Clin Sci, Clayton, Vic, Australia

[17] Monash Hlth, Diabet & Vasc Med Unit, Clayton, Vic, Australia

[18] Deakin Univ, Fac Hlth, Sch Med, Geelong, Vic, Australia

[19] Barwon Hlth, Child Hlth Res Unit, Geelong, Vic, Australia

[20] Womens & Childrens Hosp Adelaide, Endocrinol & Diabet Dept, North Adelaide, SA, Australia

来源：

BMJ OPEN DIABETES RESEARCH & CARE | 2024年 / 12卷 / 04期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Pregnancy; Islet Autoimmunity; Diabetes Mellitus; Type; 1; Cohort Studies; IMMUNE-RESPONSES; RISING INCIDENCE; AUTOANTIBODIES; OUTCOMES; PREVALENCE; NATIONWIDE; MARKERS; OBESITY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction The Environmental Determinants of Islet Autoimmunity (ENDIA) Study is an ongoing Australian prospective cohort study investigating how modifiable prenatal and early-life exposures drive the development of islet autoimmunity and type 1 diabetes (T1D) in children. In this profile, we describe the cohort's parental demographics, maternal and neonatal outcomes and human leukocyte antigen (HLA) genotypes.Research design and methods Inclusion criteria were an unborn child, or infant aged less than 6 months, with a first-degree relative (FDR) with T1D. The primary outcome was persistent islet autoimmunity, with children followed until a T1D diagnosis or 10 years of age. Demographic data were collected at enrollment. Lifestyle, clinical and anthropometric data were collected at each visit during pregnancy and clinical pregnancy and birth data were verified against medical case notes. Data were compared between mothers with and without T1D. HLA genotyping was performed on the ENDIA child and all available FDRs.Results The final cohort comprised 1473 infants born to 1214 gestational mothers across 1453 pregnancies, with 80% enrolled during pregnancy. The distribution of familial T1D probands was 62% maternal, 28% paternal and 11% sibling. The frequency of high-risk HLA genotypes was highest in T1D probands, followed by ENDIA infants, and lowest among unaffected family members. Mothers with T1D had higher rates of pregnancy complications and perinatal intervention, and larger babies of shorter gestation. Parent demographics were comparable to the Australian population for age, parity and obesity. A greater percentage of ENDIA parents were Australian born, lived in a major city and had higher socioeconomic advantage and education.Conclusions This comprehensive profile provides the context for understanding ENDIA's scope, methodology, unique strengths and limitations. Now fully recruited, ENDIA will provide unique insights into the roles of early-life factors in the development of islet autoimmunity and T1D in the Australian environment.Trial registration number ACTRN12613000794707.

引用

页码：1 / 1

页数：1

共 51 条

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Ziegler, Anette-Gabriele ;

Achenbach, Peter ;

Berner, Reinhard ;

Casteels, Kristina ;

Danne, Thomas ;

Guendert, Melanie ;

Hasford, Joerg ;

Hoffmann, Verena Sophia ;

Kordonouri, Olga ;

Lange, Karin ;

Larsson, Helena Elding ;

Lundgren, Markus ;

Snape, Matthew D. ;

Szypowska, Agnieszka ;

Todd, John A. ;

Bonifacio, Ezio .

BMJ OPEN, 2019, 9 (06)

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