Molecular subtypes of ischemic heart disease based on circadian rhythm

被引：0

作者：

Zhou, Zhaokai ^{[1
,2
]}

Zhang, Ge ^{[3
]}

Wang, Zhan ^{[2
]}

Xu, Yudi ^{[4
]}

Qin, Hongzhuo ^{[4
]}

Zhang, Haonan ^{[5
]}

Zhang, Pengpeng ^{[6
]}

Li, Zhengrui ^{[7
]}

Xu, Shuai ^{[8
,9
]}

Tan, Xin ^{[8
,9
]}

Zeng, Yiyao ^{[8
]}

Yu, Fengyi ^{[3
]}

Zhu, Shanshan ^{[10
]}

Chang, Le ^{[11
]}

Zheng, Youyang ^{[12
]}

Han, Xinwei ^{[1
,13
,14
]}

机构：

[1] Zhengzhou Univ, Dept Intervent Radiol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Dept Urol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[3] Zhengzhou Univ, Dept Cardiol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[4] Zhengzhou Univ, Dept Neurol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[5] Zhengzhou Univ, Dept Thyroid Surg, Affiliated Hosp 1, Zhengzhou, Peoples R China

[6] Tianjin Med Univ, Dept Lung Canc, Tianjin Lung Canc Ctr, Natl Clin Res Ctr Canc,Canc Inst & Hosp,Key Lab C, Tianjin, Peoples R China

[7] Shanghai Jiao Tong Univ, Shanghai Ninth Peoples Hosp, Dept Oral & Maxillofacial Head & Neck Oncol, Sch Med, Shanghai, Peoples R China

[8] Soochow Univ, Suzhou Dushu Lake Hosp, Dept Cardiol, Med Ctr,Affiliated Hosp 4, Suzhou 215000, Peoples R China

[9] Soochow Univ, Inst Hypertens, Suzhou 215000, Peoples R China

[10] Zhengzhou Univ, Dept Gastroenterol, Affiliated Hosp 1, 1 Jianshe East Rd, Zhengzhou, Peoples R China

[11] Zhengzhou Univ, Sch Med, Zhengzhou, Peoples R China

[12] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Natl Clin Res Ctr Cardiovasc Dis,Dept Cardiol, Beijing, Peoples R China

[13] Zhengzhou Univ, Intervent Inst, Zhengzhou 450052, Henan, Peoples R China

[14] Intervent Treatment & Clin Res Ctr Henan Prov, Zhengzhou 450052, Henan, Peoples R China

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

Bioinformatics; Circadian rhythm; Ischemic heart disease; Transcriptome; DISRUPTION; ATHEROSCLEROSIS; INFLAMMATION; PROGRESSION; REVEALS; CYCLE;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coronary atherosclerotic heart disease (CAD) is among the most prevalent chronic diseases globally. Circadian rhythm disruption (CRD) is closely associated with the progression of various diseases. However, the precise role of CRD in the development of CAD remains to be elucidated. The Circadian rhythm disruption score (CRDscore) was employed to quantitatively assess the level of CRD in CAD samples. Our investigation revealed a significant association between high CRDscore and adverse prognosis in CAD patients, along with a substantial correlation with CAD progression. Remarkably distinct CRDscore distributions were also identified among various subtypes. In summary, we have pioneered the revelation of the relationship between CRD and CAD at the single-cell level and established reliable markers for the development, treatment, and prognosis of CAD. A deeper understanding of these mechanisms may offer new possibilities for incorporating "the therapy of coronary heart disease based circadian rhythm" into personalized medical treatment regimens.

引用

页数：13

共 52 条

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