Autophagy-associated non-coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

被引：0

作者：

Hussain, Md Sadique ^{[3
]}

Moglad, Ehssan ^{[4
]}

Afzal, Muhammad ^{[5
]}

Sharma, Shilpa ^{[6
]}

Gupta, Gaurav ^{[2
,7
]}

Sivaprasad, G. V. ^{[8
]}

Deorari, Mahamedha ^{[9
]}

Almalki, Waleed Hassan ^{[10
]}

Kazmi, Imran ^{[11
]}

Alzarea, Sami I. ^{[12
]}

Shahwan, Moyad ^{[2
,13
]}

Pant, Kumud ^{[14
,15
]}

Ali, Haider ^{[16
,17
]}

Singh, Sachin Kumar ^{[18
,19
]}

Dua, Kamal ^{[19
,20
,21
]}

Subramaniyan, Vetriselvan ^{[1
,22
]}

机构：

[1] Monash Univ, Jeffrey Cheah Sch Med & Hlth Sci, Pharmacol Unit, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul, Malaysia

[2] Ajman Univ, Ctr Med & Bioallied Hlth Sci Res, Ajman, U Arab Emirates

[3] Jaipur Natl Univ, Sch Pharmaceut Sci, Jaipur, Rajasthan, India

[4] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia

[5] Batterjee Med Coll, Dept Pharmaceut Sci, Pharm Program, Jeddah, Saudi Arabia

[6] Chandigarh Pharm Coll, Chandigarh Grp Coll, Mohali, Punjab, India

[7] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India

[8] Raghu Engn Coll, Dept Basic Sci & Humanities, Visakhapatnam, India

[9] Uttaranchal Univ, Uttaranchal Inst Pharmaceut Sci, Dehra Dun, India

[10] Umm Al Qura Univ, Coll Pharm, Dept Pharmacol, Mecca, Saudi Arabia

[11] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia

[12] Jouf Univ, Coll Pharm, Dept Pharmacol, Sakaka, Al Jouf, Saudi Arabia

[13] Ajman Univ, Coll Pharm & Hlth Sci, Dept Clin Sci, Ajman, U Arab Emirates

[14] Graph Era Deemed Univ, Dehra Dun, India

[15] Graph Era Hill Univ, Dehra Dun, India

[16] Saveetha Univ, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Saveetha Med Coll, Chennai, India

[17] Kyrgyz State Med Coll, Dept Pharmacol, Bishkek, Kyrgyzstan

[18] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India

[19] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW, Australia

[20] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW, Australia

[21] Uttaranchal Univ, Uttaranchal Inst Pharmaceut Sci, Dehra Dun, India

[22] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Pharmacol Unit, Bandar Sunway, Selangor Darul, Malaysia

来源：

CNS NEUROSCIENCE & THERAPEUTICS | 2024年 / 30卷 / 05期

关键词：

autophagy; ncRNA; neuroinflammation; Parkinson's disease; alpha-synuclein; ALPHA-SYNUCLEIN AGGREGATION; NEAT1 PROMOTES AUTOPHAGY; BLOOD-BRAIN-BARRIER; DOPAMINERGIC-NEURONS; REGULATES APOPTOSIS; L-DOPA; MEDIATED AUTOPHAGY; CELL APOPTOSIS; MPTP MODEL; EXPRESSION;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The precise etiology of PD remains unclear, but emerging evidence suggests a significant role for disrupted autophagy-a crucial cellular process for maintaining protein and organelle integrity. Methods: This review focuses on the role of non-coding RNAs (ncRNAs) in modulating autophagy in PD. We conducted a comprehensive review of recent studies to explore how ncRNAs influence autophagy and contribute to PD pathophysiology. Special attention was given to the examination of ncRNAs' regulatory impacts in various PD models and patient samples. Results: Findings reveal that ncRNAs are pivotal in regulating key processes associated with PD progression, including autophagy, alpha-synuclein aggregation, mitochondrial dysfunction, and neuroinflammation. Dysregulation of specific ncRNAs appears to be closely linked to these pathogenic processes. Conclusion: ncRNAs hold significant therapeutic potential for addressing autophagy-related mechanisms in PD. The review highlights innovative therapeutic strategies targeting autophagy-related ncRNAs and discusses the challenges and prospective directions for developing ncRNA-based therapies in clinical practice. The insights from this study underline the importance of ncRNAs in the molecular landscape of PD and their potential in novel treatment approaches.

引用

页数：19