Seroprevalence of Protective Antibodies Against Influenza and the Reduction of the Influenza Incidence Rate: An Annual Repeated Cross-Sectional Study From 2014 to 2019

被引：0

作者：

Guiomar, Raquel ^{[1
]}

Pereira da Silva, Susana ^{[2
]}

Costa, Ines ^{[1
]}

Conde, Patricia ^{[1
]}

Cristovao, Paula ^{[1
]}

Rodrigues, Ana Paula ^{[2
]}

Fernandes, Aida ^{[3
]}

Dias, Ana Paula ^{[4
]}

Couto, Ana Rita ^{[5
]}

Ramos, Angelica ^{[6
,7
]}

Moita, Carina ^{[8
]}

Rodrigues, Carina ^{[9
]}

Vale, Fatima ^{[8
]}

Caldeira, Filomena ^{[9
]}

Bruges Armas, Jacome ^{[5
]}

Pereira-Vaz, Joao ^{[10
]}

Alves, Jose ^{[11
]}

Freitas, Ludivina ^{[11
]}

Martins, Luis ^{[12
]}

Milho, Luis ^{[3
]}

Mota-Vieira, Luisa ^{[13
]}

Lopes, Lurdes ^{[14
]}

Freitas, Margarida ^{[15
]}

Pessanha, Maria Ana ^{[4
]}

Correia, Maria ^{[10
]}

Marques, Maria Helena ^{[16
]}

Cardoso, Maria Joao ^{[6
]}

Peres, Maria Joao ^{[17
]}

Cunha, Mario ^{[12
]}

Amantegui, Patricia ^{[18
]}

Mota, Paula ^{[15
]}

Lopes, Paulo ^{[19
]}

Pereira, Paulo ^{[16
]}

Viseu, Regina ^{[17
]}

Cabral, Rita ^{[13
]}

Corte-Real, Rita ^{[14
]}

Almeida, Sofia ^{[18
]}

Soares, Vania ^{[19
]}

Mansinho, Kamal ^{[4
]}

Hungnes, Olav ^{[20
]}

Nunes, Baltazar ^{[2
]}

机构：

[1] Natl Inst Hlth Dr Ricardo Jorge IP, Infect Dis Dept, Natl Reference Lab Influenza & Other Resp Viruses, Lisbon, Portugal

[2] Natl Inst Hlth Dr Ricardo Jorge IP, Dept Epidemiol, Lisbon, Portugal

[3] Lab Saude Publ Dra Laura Ayres, Faro, Portugal

[4] Ctr Hosp Lisboa Ocidental, EPE, Lisbon, Portugal

[5] Hosp Santo Espirito Ilha Terceira, EPER, Angra Do Heroismo, Portugal

[6] Ctr Hosp Univ Sao Joao, EPE, Porto, Portugal

[7] Univ Porto, Inst Saude Publ, EPIUnit, Porto, Portugal

[8] EPE, Unidade Local Saude Guarda, Guarda, Portugal

[9] Hosp Espirito Santo Evora, EPE, Evora, Portugal

[10] Ctr Hosp & Univ Coimbra, EPE, Coimbra, Portugal

[11] Hosp Cent & Univ Madeira, Funchal, Portugal

[12] Inst Portugues Oncol Francisco Gentil, EPE, Lisbon, Portugal

[13] Hosp Divino Espirito Santo Ponta Delgada, EPER, Ponta Delgada, Portugal

[14] Ctr Hosp & Univ Lisboa Cent, EPE, Lisbon, Portugal

[15] Hosp Senhora Oliveira Guimaraes, EPE, Guimaraes, Portugal

[16] Ctr Hosp Univ Porto, EPE, Porto, Portugal

[17] Ctr Hosp Setubal, EPE, Setubal, Portugal

[18] Ctr Hosp Univ Cova Beira, EPE, Covilha, Portugal

[19] Ctr Hosp Vila Nova De Gaia Espinho, EPE, Vila Nova De Gaia Espinho, Portugal

[20] Norwegian Inst Publ Hlth, Norwegian Natl Influenz Ctr, Oslo, Norway

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2024年 / 18卷 / 05期

关键词：

antibodies; ILI incidence rate; influenza; seroprevalence; HOUSEHOLDS;

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

BackgroundSeroepidemiological studies provide estimates of population-level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. We assessed the seroprevalence of protective antibodies against influenza and evaluated the correlation of seroprevalence with the cumulative annual influenza incidence rate.MethodsWe conducted an annual repeated cross-sectional seroepidemiological survey, during June-August, from 2014 to 2019, in Portugal. A total of 4326 sera from all age groups, sex, and regions was tested by hemagglutination inhibition assay. Seroprevalence and geometric mean titers (GMT) of protective antibodies against influenza were assessed by age group, sex, and vaccine status (65+ years old). The association between summer annual seroprevalence and the difference of influenza incidence rates between one season and the previous one was measured by Pearson correlation coefficient (r).ResultsSignificant differences in seroprevalence of protective antibodies against influenza were observed in the population. Higher seroprevalence and GMT for A(H1N1)pdm09 and A(H3N2) were observed in children (5-14); influenza B seroprevalence in adults 65+ was 1.6-4.4 times than in children (0-4). Vaccinated participants (65+) showed significant higher seroprevalence/GMT for influenza. A strong negative and significant correlation was found between seroprevalence and ILI incidence rate for A(H1N1)pdm09 in children between 5 and 14 (r = -0.84; 95% CI, -0.98 to -0.07); a weak negative correlation was observed for A(H3N2) and B/Yamagata (r <= -0.1).ConclusionsThe study provides new insight into the anti-influenza antibodies seroprevalence measured in summer on the ILI incidence rate in the next season and the need for adjusted preventive health care measures to prevent influenza infection and transmission.

引用

页数：13

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