Pd(0)-Catalyzed Intermolecular Methylene C(sp3)-H Silylation by Using N-Heterocyclic Carbene Ligands

被引：0

作者：

Zhang, Zhengyang ^{[1
]}

Wei, Feng ^{[1
]}

Wang, Xuan ^{[2
]}

Zhang, Yanghui ^{[1
]}

机构：

[1] Tongji Univ, Sch Chem Sci & Engn, Shanghai Key Lab Chem Assessment & Sustainabil, Shanghai 200092, Peoples R China

[2] Shanghai Univ, Coll Sci, Dept Chem, Shanghai 200444, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 17期

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

ALPHA-AMINO-ACIDS; PALLADIUM-CATALYZED ALKYLATION; C-H SILYLATION; STEREOSELECTIVE-SYNTHESIS; COUPLING REACTIONS; BONDS; ARYLATION; ACTIVATION; FUNCTIONALIZATION; CONSTRUCTION;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct functionalization of methylene C(sp(3))-H bonds is one of the greatest challenges in transition metal-catalyzed C-H activation. Although Pd(0)-catalyzed intramolecular cyclization reactions of methylene C(sp(3))-H bonds have been reported, intermolecular functionalization remains to be discovered. Herein, we report the first example of a Pd(0)-catalyzed intermolecular methylene C(sp(3))-H functionalization reaction. By use of a N-heterocyclic carbene ligand, the methylene C(sp(3))-H bonds of 1-(benzyloxy)-2-iodobenzenes are activated and disilylated with hexamethyldisilane, affording disilylated products.

引用

页码：3586 / 3590

页数：5

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