Rhodium(III)-Catalyzed Switchable β-C(sp2)-H Alkenylation and Alkylation of Acyclic Enamides with Allyl Alcohols

被引：0

作者：

Li, Xiaolan ^{[1
,2
]}

Liu, Jie ^{[2
]}

Song, Ruixin ^{[2
]}

Luo, Xuzhong ^{[1
,2
]}

Luo, Haiqing ^{[2
]}

机构：

[1] Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China

[2] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 17期

基金：

中国国家自然科学基金;

关键词：

C-H ARYLATION; FUNCTIONALIZATION; TRIFLUOROMETHYLATION; PHOSPHORYLATION; DERIVATIVES; OLEFINATION; ACTIVATION; MECHANISM; ACYLATION; ALDEHYDES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, rhodium(III)-catalyzed beta-C(sp(2))-H alkenylation and alkylation of enamides are presented using readily accessible allylic alcohols by switching the reaction conditions. This tunable transformation has been applied to a wide range of substrates and typically proceeded with excellent regioselectivity and stereoselectivity as well as with good functional group tolerance. The catalytic system offers an efficient approach for synthesizing various functionalized enamides bearing N-(2Z,4E)-butadiene and (Z)-beta-C(sp(2))-H alkylated enamides. In addition, mechanistic experiments suggest that Rh(III)-catalyzed C-H activation is not related to the critical step.

引用

页码：3673 / 3678

页数：6

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