Effects of mitochondrial transplantation on chronic pressure wound healing in a human patient

Background aims: Wound healing is a multistage process that requires a concerted effort of various cell types. The intricate processes involved in the healing of wounds result in high energy requirements. Furthermore, mitochondria play a crucial role in the healing process because of their involvement in neo angiogenesis, growth factor synthesis, and cell differentiation. It is unclear how mitochondria transplantation, a promising new approach, influences wound healing. Methods: In this study, healthy autologous mitochondria obtained from skeletal muscle were injected into chronic pressure wounds as an intervention to promote wound healing. Results: Mitochondrial transplantation accelerated wound healing by reducing wound size, increasing granulation tissue, and hastening epithelialization. Conclusions: This study is the first to demonstrate the therapeutic efficacy of mitochondrial transplantation in wound healing. (c) 2024 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.