Chemical composition and cytotoxicity of Garcinia urophylla Scort. ex King essential oil

被引：0

作者：

Adward, Keith Katrina ^{[1
]}

Salleh, Wan Mohd Nuzul Hakimi Wan ^{[1
,2
]}

Salihu, Abubakar Siddiq ^{[1
,3
]}

Ghani, Nurunajah Ab ^{[4
,5
]}

Arzmi, Mohd Hafiz ^{[6
]}

Khamis, Shamsul ^{[2
,7
]}

机构：

[1] Univ Pendidikan Sultan Idris, Dept Chem, Fac Sci & Math, Tanjong Malim, Perak, Malaysia

[2] Univ Kebangsaan Malaysia, Frasers Hill Res Ctr, Bangi, Selangor, Malaysia

[3] Umaru Musa Yaradua Univ, Fac Nat & Appl Sci, Dept Pure & Appl Sci, Katsina, Nigeria

[4] Univ Teknol MARA, Atta Ur Rahman Inst Nat Product Discovery AuRIns, Puncak Alam, Selangor, Malaysia

[5] Univ Teknol MARA, Fac Appl Sci, Shah Alam, Selangor, Malaysia

[6] Int Islamic Univ Malaysia, Dept Fundamental Dent & Med Sci Kulliyyah Dent, Kuantan, Pahang, Malaysia

[7] Univ Kebangsaan Malaysia, Fac Sci & Technol, Dept Biol Sci & Biotechnol, Bangi, Selangor, Malaysia

来源：

RIVISTA ITALIANA DELLE SOSTANZE GRASSE | 2024年 / 101卷 / 01期

关键词：

Essential oil; Garcinia urophylla; beta-caryophyllene; cytotoxicity; LEAVES; MANGOSTANA; EXTRACTS;

D O I：

暂无

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Essential oils, a volatile mixture derived from plants, have shown a wide biological activity, and have been used as ancient remedies for the treatment of various diseases. The objective of this study was to investigate the chemical composition and cytotoxicity of the essential oil obtained from Garcinia urophylla leaves collected from Malaysia. Eighteen components were identified using gas chromatography -flame ionisation detection (GCFID) and gas chromatography/mass spectrometry (GC -MS), which represent 99.9% of the essential oil. The major components were beta-caryophyllene (56.2%), alpha-humulene (26.3%), and alpha-gurjunene (6.3%). The cytotoxicity of essential oil was evaluated using an MTT assay. The essential oil exhibited cytotoxicity against three cancer cell lines which are HepG2, MCF7, and A549 with the IC50 values of 71.5, 56.2, and 68.5 mu g/ mL, respectively. To the best of our knowledge, this is the first report on the essential oil composition obtained from Garcinia urophylla , which may have implications on the pharmaceutical and therapeutic applications of Garcinia genus essential oils.

引用

页数：70

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