Genetic associations with psychosis and affective disturbance in Alzheimer's disease

被引：0

作者：

Antonsdottir, Inga Margret ^{[1
,2
]}

Creese, Byron ^{[3
]}

Klei, Lambertus ^{[4
]}

DeMichele-Sweet, Mary Ann A. ^{[4
]}

Weamer, Elise A. ^{[5
]}

Garcia-Gonzalez, Pablo ^{[6
,7
]}

Marquie, Marta ^{[6
,7
]}

Boada, Merce ^{[6
,7
]}

Alarcon-Martin, Emilio ^{[6
]}

Valero, Sergi ^{[6
,7
]}

Liu, Yushi ^{[8
]}

Hooli, Basavaraj ^{[9
]}

Aarsland, Dag ^{[10
]}

Selbaek, Geir ^{[11
,12
]}

Bergh, Sverre ^{[13
]}

Rongve, Arvid ^{[14
,15
]}

Saltvedt, Ingvild ^{[16
]}

Skjellegrind, Havard K. ^{[17
,18
]}

Engdahl, Bo ^{[19
]}

Andreassen, Ole A. ^{[20
]}

Borroni, Barbara ^{[21
]}

Mecocci, Patrizia ^{[22
,23
]}

Wedatilake, Yehani ^{[13
]}

Mayeux, Richard ^{[24
,25
,26
]}

Foroud, Tatiana ^{[27
]}

Ruiz, Agustin ^{[6
,7
]}

Lopez, Oscar L. ^{[4
,5
]}

Kamboh, M. Ilyas ^{[4
]}

Ballard, Clive ^{[3
]}

Devlin, Bernie ^{[28
]}

Lyketsos, Constantine ^{[2
]}

Sweet, Robert A. ^{[4
,5
]}

机构：

[1] Johns Hopkins Sch Nursing, Baltimore, MD USA

[2] Richman Family Precis Med Ctr Excellence Alzheime, Dept Psychiat & Behav Sci, Johns Hopkins Bayview, Johns Hopkins Med, Baltimore, MD USA

[3] Univ Exeter, Fac Hlth & Life Sci, Dept Clin & Biomed Sci, Exeter, Devon, England

[4] Univ Pittsburgh, Dept Psychiat, Biomed Sci Tower,Room W-1645,3811 OHara St, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA USA

[6] UIC, ACE Alzheimer Ctr Barcelona, Res Ctr & Memory Clin, Barcelona, Spain

[7] Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

[8] Eli Lilly & Co, Lilly Res Labs, Global Stat Sci, Indianapolis, IN USA

[9] Eli Lilly & Co, Lilly Res Labs, Neurodegenerat Res, Indianapolis, IN USA

[10] Kings Coll London, Dept Old Age Psychiat, Inst Psychiat Psychol & Neurosci, London, England

[11] Vestfold Hosp Trust, Norwegian Natl Ctr Aging & Hlth, Tonsberg, Norway

[12] Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway

[13] Innlandet Hosp Trust, Res Ctr Age Related Funct Decline & Dis, Ottestad, Norway

[14] Helse Fonna, Dept Res & Innovat, Haugesund, Norway

[15] Univ Bergen, Dept Clin Med K1, Bergen, Norway

[16] Univ Hosp Trondheim, St Olav Hosp, Dept Geriatr, Trondheim, Norway

[17] Nord Trondelag Hosp Trust, Nord Trondelag, Norway

[18] Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, HUNT Res Ctr, Dept Publ Hlth & Nursing, Levanger, Norway

[19] Norwegian Inst Publ Hlth, Oslo, Norway

[20] Univ Oslo, Inst Clin Med, NORMENT, Oslo, Norway

[21] Univ Brescia, Ctr Neurodegenerat Disorders, Brescia, Italy

[22] Univ Perugia, Inst Gerontol & Geriatr, Perugia, Italy

[23] Karolinska Inst, Geriatr Clin, NVS, Stockholm, Sweden

[24] Columbia Univ, Dept Neurol, New York, NY USA

[25] Columbia Univ, Dept Psychiat, New York, NY USA

[26] Columbia Univ, Dept Epidemiol, New York, NY USA

[27] Indiana Univ Sch Med, Med & Mol Genet, Indianapolis, IN USA

[28] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2024年 / 10卷 / 02期

关键词：

affective disturbance; Alzheimer's disease; genome-wide association; heritability; psychosis; INCREASED FAMILIAL RISK; BRIEF CLINICAL FORM; NEUROPSYCHIATRIC INVENTORY; BEHAVIORAL DISTURBANCES; CACHE COUNTY; NPI-Q; DEMENTIA; SYMPTOMS; CONSORTIUM; CITALOPRAM;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Individuals with Alzheimer's disease (AD) commonly experience neuropsychiatric symptoms of psychosis (AD+P) and/or affective disturbance (depression, anxiety, and/or irritability, AD+A). This study's goal was to identify the genetic architecture of AD+P and AD+A, as well as their genetically correlated phenotypes. METHODS: Genome-wide association meta-analysis of 9988 AD participants from six source studies with participants characterized for AD+P AD+A, and a joint phenotype (AD+A+P). RESULTS: AD+P and AD+A were genetically correlated. However, AD+P and AD+A diverged in their genetic correlations with psychiatric phenotypes in individuals without AD. AD+P was negatively genetically correlated with bipolar disorder and positively with depressive symptoms. AD+A was positively correlated with anxiety disorder and more strongly correlated than AD+P with depressive symptoms. AD+P and AD+A+P had significant estimated heritability, whereas AD+A did not. Examination of the loci most strongly associated with the three phenotypes revealed overlapping and unique associations. DISCUSSION: AD+P, AD+A, and AD+A+P have both shared and divergent genetic associations pointing to the importance of incorporating genetic insights into future treatment development.

引用

页数：11

共 51 条

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