Photo- and Cu-Mediated 11C Cyanation of (Hetero)Aryl Thianthrenium Salts

被引：0

作者：

Cheng, Kevin ^{[1
]}

Webb, E. William ^{[1
]}

Bowden, Gregory D. ^{[1
,2
,3
]}

Wright, Jay S. ^{[1
]}

Shao, Xia ^{[1
]}

Sanford, Melanie S. ^{[4
]}

Scott, Peter J. H. ^{[1
]}

机构：

[1] Univ Michigan, Dept Radiol, Med Sch, Ann Arbor, MI 48109 USA

[2] Eberhard Karls Univ Tubingen, Werner Siemens Imaging Ctr, Dept Preclin Imaging & Radiopharm, D-72074 Tubingen, Germany

[3] Eberhard Karls Univ Tubingen, Dept Phamacol & Expt Therapy, Cluster Excellence iFIT EXC 2180 Image Guided & Fu, D-72074 Tubingen, Germany

[4] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 16期

基金：

美国国家卫生研究院;

关键词：

ARENES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present a photo- and Cu-mediated C-11 cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium substrates can be readily accessed via C-H functionalization, and the radiocyanation protocol proceeds under mild conditions (<50 degrees C, 5 min) and can be automated using open-source, readily accessible augmentations to existing radiochemistry equipment.

引用

页码：3419 / 3423

页数：5

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