An Extensive Analysis of Current Synthetic Methodologies and Applications of Imidazo/Benzimidazo[1,2-c]Quinazolines

A great deal of attention has been received on developing N-heterocyclic compounds due to their ambitious biological activities. Many of them are essential footstep to the development and discovery of new drugs. Imidazole/benzimidazole and quinazoline are essential pharmacologically active N-heterocycles, and one of the molecular framework built up from their combination, imidazo/benzimidazo[1,2-c]quinazoline, is of great attention in terms of synthesis, reactions, and medicinal applications. The positional variation of hetero N-atoms and the functional groups acting as substituents in the main scaffold have a direct impact on the properties of imidazo/benzimidazo[1,2-c]quinazolines. In addition to its physiological activities, this moiety is useful for electrical conductivity, molecules/ions sensing, coordination complex and coordination polymer (CP) formation, and their diverse applications. The major objective of this review is to highlight various synthetic approaches for imidazo/benzimidazo[1,2-c]quinazolines motif since 2000. Toxicant-free reaction conditions and the use of an extensive range of inexpensive substrates are two of the main practical benefits of the protocol in accomplishing the sustainable development goals.