Serum MRGPRX2 as a Long-term Biomarker for Iodinated Contrast Media-Induced Anaphylaxis

被引：0

作者：

An, Jin ^{[1
]}

Lee, Chea Eun ^{[2
]}

Kim, Seo-Young ^{[2
]}

Park, So -Young ^{[3
]}

Kim, Sujeong ^{[4
]}

Sim, Da Woon ^{[5
]}

Yang, Min-Suk ^{[6
]}

Park, Han-Ki ^{[7
]}

Kim, Sae-Hoon ^{[8
,9
]}

Kim, Sang-Heon

Ye, Young-Min ^{[10
]}

Lee, Jae Hyun ^{[11
]}

Hur, Gyu Young ^{[12
]}

Park, Hye-Kyung ^{[13
]}

Koh, Youngil

Park, Jung-Won ^{[11
]}

Lee, Jaechun ^{[14
]}

Lee, Byung-Jae ^{[15
]}

Kim, Tae -Bum ^{[2
]}

机构：

[1] Kyung Hee Univ, Coll Med, Kyung Hee Univ Hosp Gangdong, Dept Pulm Allergy & Crit Care Med, Seoul, South Korea

[2] Univ Ulsan, Asan Med Ctr, Dept Allergy & Clin Immunol, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea

[3] Chung Ang Univ, Coll Med, Div Pulm Allergy & Crit Care Med, Dept Internal Med,Gwangmyeong Hosp, Seoul, South Korea

[4] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea

[5] Chonnam Natl Univ, Med Sch, Chonnam Natl Univ Hosp, Dept Allergy & Clin Immunol, Gwangju, South Korea

[6] Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul Metropolitan Govt, Seoul, South Korea

[7] Kyungpook Natl Univ, Sch Med, Dept Allergy & Clin Immunol, Chilgok Hosp, Daegu 41404, South Korea

[8] Seoul Natl Univ, Div Allergy & Clin Immunol, Dept Internal Med, Bundang Hosp, Seongnam, South Korea

[9] Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[10] Ajou Univ, Sch Med, Dept Allergy & Clin Immunol, Suwon, South Korea

[11] Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea

[12] Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea

[13] Pusan Natl Univ, Dept Internal Med, Coll Med, Busan, South Korea

[14] Jeju Natl Univ, Jeju Natl Univ Hosp, Dept Internal Med, Sch Med, Jeju, South Korea

[15] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea

来源：

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | 2024年 / 16卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Hypersensitivity; drug; anaphylaxis; tryptase; HYPERSENSITIVITY REACTIONS; DIAGNOSIS;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The diagnosis of anaphylaxis is based on the clinical history. The utility of tryptase measurements in clinical setting is limited. Mas-related G protein -coupled receptor -X2 (MRGPRX2) is expressed in mast cells and is involved in the degranulation of these cells. We evaluated the potential of MRGPRX2 as a diagnostic biomarker in patients with iodinated contrast media (ICM)-induced immediate hypersensitivity reactions (IHRs). A total of 173 patients with documented ICM-induced IHR within 4 months from registration were enrolled and skin tests for the culprit ICM were performed. The time interval was evaluated as the duration between the onset of ICM-induced IHR and the measurement of serum MRGPRX2 levels. Serum MRGPRX2 concentration was determined using an enzyme -linked immunosorbent assay kit. Of the 173 patients, 33 and 140 were included in the anaphylaxis and non -anaphylaxis groups, respectively. Serum MRGPRX2 levels were significantly higher in the anaphylaxis than in the non -anaphylaxis group (29.9 +/- 24.1 vs. 20.7 +/- 17.5, P = 0.044). Serum MRGPRX2 showed a moderate predictive ability for anaphylaxis, with an area under the curve of 0.61 ( P = 0.058). When groups were classified based on the time interval, T1(0-2months) and T2 (2-4months), patients with anaphylaxis had higher MRGPRX2 levels compared to the non -anaphylaxis group in the T2 group (36.5 +/- 19.2 vs. 20.5 +/- 19.0, P = 0.035). This pilot study shows that serum MRGPRX2 is a potential long-term biomarker for predicting anaphylaxis, particularly ICM-induced anaphylaxis. Further studies are needed to determine the role of MRGPRX2 in anaphylaxis in a larger population of patients with various drug -induced IHRs.

引用

页码：308 / 316

页数：9

共 22 条

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