Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

被引:0
|
作者
Mijung Yeom [1 ]
Sora Ahn [1 ]
DaeHyun Hahm [1 ,2 ,3 ]
SunYoung Jang [1 ,4 ]
Se Hoon Jang [1 ,4 ]
SuYang Park [1 ,4 ]
JaeHwan Jang [1 ]
Jihan Park [5 ]
JuYoung Oh [1 ]
InSeon Lee [5 ]
Kyuseok Kim [6 ]
SoonKyeong Kwon [7 ]
HiJoon Park [1 ,4 ,5 ,8 ]
机构
[1] Acupuncture and Meridian Science Research Center,College of Korean Medicine,Kyung Hee University
[2] Department of Physiology,School of Medicine,Kyung Hee University
[3] BioNanocomposite Research Center,Kyung Hee University
[4] Department of Science in Korean Medicine,College of Korean Medicine,Graduate School,Kyung Hee University
[5] College of Korean Medicine,Kyung Hee University
[6] Department of Ophthalmology,Otorhinolaryngology and Dermatology of Korean Medicine,College of Korean Medicine,Kyung Hee University
[7] Division of Applied Life Science (BK),Gyeongsang National University
[8] Department of Anatomy & Information Sciences,College of Korean Medicine,Kyung Hee
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中图分类号
R245 [针灸学、针灸疗法];
学科分类号
100512 ;
摘要
Objective: Atopic dermatitis(AD) is a chronic inflammatory skin disease that may be linked to changes in the gut microbiome. Acupuncture has been proven to be effective in reducing AD symptoms without serious adverse events, but its underlying mechanism is not completely understood. The purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut microbiota-dependent.Methods: AD-like skin lesions were induced by applying MC903 topically to the cheek of the mouse.Acupuncture was done at the Gok-Ji(LI11) acupoints. AD-like symptoms were assessed by lesion scores,scratching behavior, and histopathological changes; intestinal barrier function was measured by fecal output, serum lipopolysaccharide levels, histopathological changes, and mRNA expression of markers involved in intestinal permeability and inflammation. Gut microbiota was profiled using 16S rRNA gene sequencing from fecal samples.Results: Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening, and also significantly altered gut microbiota structure as revealed by β-diversity indices and analysis of similarities. These beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated mice. Interestingly, AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability, atrophy of the mucosal structure(reduced villus height and crypt depth), decreased expression of tight junctions and mucus synthesis genes, and increased expression of inflammatory mediators in the ileum. Acupuncture attenuated these abnormalities, which was gut microbiota-dependent.Conclusion: Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier, providing new perspective for non-pharmacological strategies for modulating gut microbiota to prevent and treat AD.
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页码:600 / 613
页数:14
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