Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage

被引：0

作者：

Li HongXing ^{[1
,2
]}

Chai YiHong ^{[1
,3
]}

Sun XiaoHong ^{[1
,3
]}

He XiaoXia ^{[1
,2
]}

Xi YaMing ^{[1
,3
]}

机构：

[1] The First School of Clinical Medicine, Lanzhou University, Lanzhou, China

[2] Key Laboratory for Reproductive Medicine and Embryo of Gansu Province, Lanzhou, China

[3] Department of Hematology, The First Hospital of Lanzhou University, Lanzhou, China

来源：

生殖与发育医学（英文） | 2024年 / 08卷 / 03期

关键词：

Hematopoietic stem cells; Differentiation; Epigenetics; Post-translational regulation;

D O I：

暂无

中图分类号：

R329.2 [人体细胞学];

学科分类号：

100101 ;

摘要：

The differentiation process from hematopoietic stem cells (HSCs) to mature red blood cells (RBCs) is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal differentiation. Erythropoiesis is the dynamic journey of HSCs through various functional and phenotypic stages. The physiological course of erythrogenesis is intricately linked to significant changes in chromatin accessibility, necessitating precise coordination of transcription factors and epigenetic elements. This review presents a comprehensive overview of recent investigations into the molecular-level epigenetic regulatory factors that influence the differentiation of the erythroid lineage. This encompasses the exploration of transcriptional, post-transcriptional, and post-translational regulatory processes. The intricate interplay of epigenetic and transcriptional regulatory networks in erythroid differentiation not only enhances our understanding of this fundamental biological process but also provides valuable insights into the underlying mechanisms contributing to the pathogenesis of disorders associated with abnormal erythroid development. These findings hold significant promise for the development of novel therapeutic strategies to address these diseases and improve patient outcomes.

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