The role of reactive oxygen species in gastric cancer

被引：0
|
作者：
Yuqi Wang [1 ,2 ,3 ,4 ]
Jingli Xu [2 ,3 ,4 ]
Zhenjie Fu [2 ,3 ,4 ]
Ruolan Zhang [2 ,3 ,4 ]
Weiwei Zhu [2 ,3 ,4 ]
Qianyu Zhao [2 ,3 ,4 ]
Ping Wang [1 ]
Can Hu [2 ,3 ,4 ]
Xiangdong Cheng [2 ,3 ,4 ]
机构：
[1] College of Pharmaceutical Sciences, Zhejiang University of Technology
[2] Department of Gastric Surgery, Zhejiang Cancer Hospital
[3] Key Laboratory of Prevention
[4] Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer
来源：
CancerBiology&Medicine | 2024年 / 21卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R735.2 [胃肿瘤];
学科分类号：
摘要：
Gastric cancer(GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species(ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.
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收藏
页码：740 / 753
页数：14
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