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Mechanochemistry of catch bonds between integrins and ligands
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作者：
Fang KongWei ChenJizhong LouCheng ZhuWoodruff School of Mechanical EngineeringInstitute for Bioengineering and Bioscienceand Coulter Department of Biomedical Engineering Georgia Institute of TechnologyAtlantaGA cheng
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中图分类号：
R318.01 [生物力学];
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摘要：
<正>Integrins are a large family of adhesion molecules broadly expressed on the surface of a wide variety of cells as heterodimers.Binding of integrins to ligands provides anchorage and signals for the cell,making them prime candidates for mechanosensing molecules.To elucidate how force regulates integrin/ligand dissociation,we used molecular mechanics experiments to
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