BCL11b调控ILC2机制的研究进展

被引：0

作者：

虞文坤

贾海英

机构：

[1] 暨南大学附属第一医院耳鼻喉科

来源：

湖北民族学院学报(医学版) | 2019年 / 36卷 / 03期

关键词：

BCL11b; ILC2; 调控; 细胞因子; 免疫性疾病;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 ;

摘要：

Ⅱ型固有淋巴细胞(ILC2)是新近发现的固有淋巴细胞群体,在Notch信号下,B细胞慢性淋巴细胞白血病/淋巴瘤11B基因(BCL11b)通过独立生长因子-1(Gfi-1)诱导GATA结合因子-3(GATA-3)调控ILC2的发育,并诱导ILC2产生炎性细胞因子。本文将对ILC2的界定、BCL11b在ILC2的表达、BCL11b介导ILC2的发育和调控ILC2产生炎性细胞因子的研究进展进行综述。这将对发现免疫性疾病和慢性疾病等的新机制以及潜在的治疗靶标具有一定的现实意义。

引用

页码：64 / 66+70 +70

页数：4

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