Association between perioperative flurbiprofen administration and acute kidney injury (AKI) in spine surgery: a retrospective cohort study

被引:0
作者
Liu, Yongrong [1 ]
Li, Bo [1 ]
Hang, Lihua [2 ]
Zhang, Li [2 ]
机构
[1] Cent South Univ, Dept Operat Ctr, Xiangya Hosp 3, Changsha 410013, Peoples R China
[2] Jiangsu Univ, Dept Anesthesiol, Peoples Hosp Kunshan 1, Kunshan 215300, Peoples R China
关键词
Flurbiprofen; NSAID; AKI; Spine surgery; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; POSTOPERATIVE PAIN; MAJOR SURGERY; OUTCOMES; RECOVERY; RISK; METAANALYSIS; CKD;
D O I
10.1186/s13741-024-00419-2
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background The association between nonsteroidal anti-inflammatory drugs (NSAIDs) and postoperative acute kidney injury (AKI) remains controversial, with limited studies specifically examining flurbiprofen. Therefore, this research aimed to investigate the association between intraoperative flurbiprofen administration and postoperative AKI. Methods We retrospectively identified a cohort of patients at the Third Xiangya Hospital of Central South University. A total of 3882 adult patients undergoing spinal surgery between January 1, 2012, and July 31, 2018, were included and classified into two groups: those receiving flurbiprofen (50 or 100 mg once, 5 min after anesthesia start) and those not receiving flurbiprofen. The primary endpoint was the incidence of AKI. Result The flurbiprofen group (4.4%) had a lower incidence of AKI compared to the non-flurbiprofen group (6.5%, P < 0.001). After adjusting for potential confounding variables, the multivariable regression analysis showed that the flurbiprofen group had a 49% reduced risk of postoperative AKI (OR 0.51; 95% CI 0.31 to 0.82) compared to the non-flurbiprofen group. Subgroup analysis indicated that flurbiprofen injection was associated with a reduced incidence of postoperative AKI in patients without diabetes (OR 0.61; 95% CI 0.19 to 0.74), surgical times of 2-5 h (OR 0.54; 95% CI 0.23 to 0.75), and preoperative anemia (OR 0.57; 95% CI 0.21 to 0.74). Conclusion The study concluded that perioperative flurbiprofen treatment was associated with a lower risk of postoperative AKI in adult patients undergoing spinal surgery.
引用
收藏
页数:8
相关论文
共 29 条
  • [1] Association between preoperative aspirin and acute kidney injury following coronary artery bypass grafting
    Aboul-Hassan, Sleiman Sebastian
    Marczak, Jakub
    Stankowski, Tomasz
    Peksa, Maciej
    Nawotka, Marcin
    Stanislawski, Ryszard
    Cichon, Romuald
    [J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2020, 160 (03) : 712 - 719
  • [3] Incidence, risk factors, and outcomes of perioperative acute kidney injury in noncardiac and nonvascular surgery
    Biteker, Murat
    Dayan, Akin
    Tekkesin, Ahmet Ilker
    Can, Mehmet M.
    Tayci, Ibrahim
    Ilhan, Erkan
    Sahin, Gulizar
    [J]. AMERICAN JOURNAL OF SURGERY, 2014, 207 (01) : 53 - 59
  • [4] Increased Risk of Chronic Kidney Disease in Rheumatoid Arthritis Associated with Cardiovascular Complications - A National Population-Based Cohort Study
    Chiu, Hsien-Yi
    Huang, Hui-Ling
    Li, Chien-Hsun
    Chen, Hung-An
    Yeh, Chia-Lun
    Chiu, Shih-Hsiang
    Lin, Wei-Chun
    Cheng, Yu-Pin
    Tsai, Tsen-Fang
    Ho, Shinn-Ying
    [J]. PLOS ONE, 2015, 10 (09):
  • [5] The effect of ketorolac on recovery after anorectal surgery: Intravenous versus local administration
    Coloma, M
    White, PF
    Huber, PJ
    Tongier, WK
    Dullye, KK
    Duffy, LL
    [J]. ANESTHESIA AND ANALGESIA, 2000, 90 (05) : 1107 - 1110
  • [6] Effects of Flurbiprofen on CRP, TNF-α, IL-6, and Postoperative Pain of Thoracotomy
    Esme, Hidir
    Kesli, Recep
    Apiliogullari, Burhan
    Duran, Ferdane Melike
    Yoldas, Banu
    [J]. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2011, 8 (03): : 216 - 221
  • [7] Fang Shin-Yuan, 2013, Acta Anaesthesiol Taiwan, V51, P120, DOI 10.1016/j.aat.2013.08.003
  • [8] Nonsteroidal Anti-inflammatory Drugs and the Risk for Anastomotic Failure A Report From Washington State's Surgical Care and Outcomes Assessment Program (SCOAP)
    Hakkarainen, Timo W.
    Steele, Scott R.
    Bastaworous, Amir
    Dellinger, E. Patchen
    Farrokhi, Ellen
    Farjah, Farhood
    Florence, Michael
    Helton, Scott
    Horton, Marc
    Pietro, Michael
    Varghese, Thomas K.
    Flum, David R.
    [J]. JAMA SURGERY, 2015, 150 (03) : 223 - 228
  • [9] Comparison of Postoperative Renal Function between Non-Steroidal Anti-Inflammatory Drug and Opioids for Patient-Controlled Analgesia after Laparoscopic Nephrectomy: A Retrospective Cohort Study
    Han, Jiwon
    Jeon, Young-Tae
    Oh, Ah-Young
    Koo, Chang-Hoon
    Bae, Yu Kyung
    Ryu, Jung-Hee
    [J]. JOURNAL OF CLINICAL MEDICINE, 2020, 9 (09)
  • [10] Acute Kidney Injury Recovery Pattern and Subsequent Risk of CKD: An Analysis of Veterans Health Administration Data
    Heung, Michael
    Steffick, Diane E.
    Zivin, Kara
    Gillespie, Brenda W.
    Banerjee, Tanushree
    Hsu, Chi-yuan
    Powe, Neil R.
    Pavkov, Meda E.
    Williams, Desmond E.
    Saran, Rajiv
    Shahinian, Vahakn B.
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2016, 67 (05) : 742 - 752