Synthesis and Antioxidant Activity of Furan Derivatives Containing a 1,3,4-Oxadiazole Ring

被引：0

作者：

Aghekyan, A. A. ^{[1
]}

Panosyan, H. A. ^{[1
]}

Buniatyan, Zh. M. ^{[1
]}

Muradyan, R. E. ^{[1
]}

Mkryan, G. G. ^{[1
]}

机构：

[1] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 04期

关键词：

furan; hydrazide; phosphoryl chloride; cyclization; 1,3,4-oxadiazole;

D O I：

10.1134/S1070428024040146

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl 5-aminomethylfuran-2-carboxylates reacted with methylamine to give 5-aminomethylN-methylfuran-2-carboxamides, and their hydrolysis afforded the corresponding carboxylic acids. The reaction of methyl 5-aminomethylfuran-2-carboxylates with hydrazine hydrate produced hydrazides which were acylated with benzoyl or 2-furoyl chloride and then subjected to heterocyclization to obtain furan derivatives containing a 1,3,4-oxadiazole ring. The target products were also synthesized in one step by reacting 5-aminomethylfuran-2-carbohydrazides with acid chlorides in the presence of phosphoryl chloride.

引用

页码：655 / 663

页数：9

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