Copper-Catalyzed Cyanoalkylation and Trifluoromethylthiolation of Styrene Derivatives via a Visible-Light-Promoted Cross-Coupling

被引：5
作者：
Xu, Xiao-Jing [1 ]
Chi, Zhuo-Min [1 ]
Rui, Rong [1 ]
Zhang, Zhe [1 ]
Li, Hong-Zhe [1 ]
Liu, Xue-Yuan [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Cyanoalkylation; trifluoromethylthiolation; difunctionalization of styrenes; copper catalysis; visible-light-promoted; CYCLOBUTANONE O-BENZOYLOXIMES; CYCLOKETONE OXIME ESTERS; C-H CYANOALKYLATION; SILVER(I) TRIFLUOROMETHANETHIOLATE; IMINYL RADICALS; CONTAINING PHARMACEUTICALS; SUBSTITUENT CONSTANTS; RING-CLEAVAGE; BOND-CLEAVAGE; ALKENES;
D O I：
10.1002/adsc.202400116
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Transition-metal catalyzed difunctionalization of olefins has attracted considerable attention as a method to construct carbon-carbon and carbon-hetero bonds. Herein, the copper-catalyzed three-component radical cross-coupling of oxime esters, styrenes and AgSCF3 through a visible-light-promoted iminyl radical-mediated carbon-carbon bond cleavage strategy has been described. Utilizing low-cost copper salt as both photosensitizers and cross-couplers, this protocol delivers diverse target products, providing a supplementary approach for cyanoalkylation and trifluoromethylthiolation of drug molecules. image
引用
收藏
页码：2607 / 2612
页数：6
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