Copper-Catalyzed Cyanoalkylation and Trifluoromethylthiolation of Styrene Derivatives via a Visible-Light-Promoted Cross-Coupling

被引：4

作者：

Xu, Xiao-Jing ^{[1
]}

Chi, Zhuo-Min ^{[1
]}

Rui, Rong ^{[1
]}

Zhang, Zhe ^{[1
]}

Li, Hong-Zhe ^{[1
]}

Liu, Xue-Yuan ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Cyanoalkylation; trifluoromethylthiolation; difunctionalization of styrenes; copper catalysis; visible-light-promoted; CYCLOBUTANONE O-BENZOYLOXIMES; CYCLOKETONE OXIME ESTERS; C-H CYANOALKYLATION; SILVER(I) TRIFLUOROMETHANETHIOLATE; IMINYL RADICALS; CONTAINING PHARMACEUTICALS; SUBSTITUENT CONSTANTS; RING-CLEAVAGE; BOND-CLEAVAGE; ALKENES;

D O I：

10.1002/adsc.202400116

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Transition-metal catalyzed difunctionalization of olefins has attracted considerable attention as a method to construct carbon-carbon and carbon-hetero bonds. Herein, the copper-catalyzed three-component radical cross-coupling of oxime esters, styrenes and AgSCF3 through a visible-light-promoted iminyl radical-mediated carbon-carbon bond cleavage strategy has been described. Utilizing low-cost copper salt as both photosensitizers and cross-couplers, this protocol delivers diverse target products, providing a supplementary approach for cyanoalkylation and trifluoromethylthiolation of drug molecules. image

引用

页码：2607 / 2612

页数：6

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