Survival associated with the use of one-step nucleic acid amplification (OSNA) to detect sentinel lymph node metastasis in cervical cancer

被引:3
作者
Bizzarri, Nicolo [4 ,5 ]
Fedele, Camilla
Teodorico, Elena
Certelli, Camilla
Anchora, Luigi Pedone
Carbone, Vittoria
Giannarelli, Diana [1 ]
Fagotti, Anna [3 ]
Zannoni, Gian Franco [2 ,3 ]
Valente, Michele [2 ,3 ]
Querleu, Denis
Ferrandina, Gabriella [3 ]
Scambia, Giovanni [3 ]
Fanfani, Francesco [3 ]
机构
[1] Fdn Policlin Univ A Gemelli, IRCCS, UOC Ginecol Oncolog, Dipartimento Sci Salute Donna Bambino & Sanita Pub, Rome, Italy
[2] Fdn Policlin Univ A Gemelli, IRCCS, Biostat Unit, Sci Directorate, Rome, Italy
[3] Fdn Policlin Univ A Gemelli, IRCCS, Dipartimento Sci Salute Donna, Gynecopathol & Breast Pathol Unit,Bambino & San Pu, Rome, Italy
[4] Univ Cattolica Sacro Cuore, Rome, Italy
[5] Fdn Policlin Univ A Gemelli, IRCCS, UOC Ginecol Oncolog, Dipartimento Sci Salute Donna Bambino & San Pubbl, I-00168 Rome, Italy
来源
EJSO | 2024年 / 50卷 / 04期
关键词
Cervical cancer; One -step nucleic acid amplification; OSNA; Ultrastaging; Survival; Sentinel lymph node; MULTICENTER;
D O I
10.1016/j.ejso.2024.108250
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction: Sentinel lymph node (SLN) biopsy is part of surgical treatment of apparent early-stage cervical cancer. SLN is routinely analyzed by ultrastaging and immunohistochemistry. The aim of this study was to assess the survival of patients undergoing SLN analyzed by one -step nucleic acid amplification (OSNA) compared with ultrastaging. Methods: Single-center, retrospective, cohort study. Patients undergoing primary surgery and SLN mapping ( +/- pelvic lymphadenectomy) for apparent early-stage cervical cancer between May 2017 and January 2021 were included. SLN was analyzed exclusively with OSNA or with ultrastaging. Patients with bilateral SLN mapping failure, with SLN analyzed alternatively/serially with OSNA and ultrastaging, and undergoing neo-adjuvant therapy were excluded. Baseline clinic-pathological differences between the two groups were balanced with propensity-match analysis. Results: One-hundred and fifty-seven patients were included, 50 (31.8%) in the OSNA group and 107 (68.2%) in the ultrastaging group. Median follow up time was 41 months (95%CI:37.9-42.2). 5-year DFS in patients undergoing OSNA versus ultrastaging was 87.0% versus 91.0% (p = 0.809) and 5-year overall survival was 97.9% versus 98.6% (p = 0.631), respectively. No difference in the incidence of lymph node recurrence between the two groups was noted (OSNA 20.0% versus ultrastaging 18.2%, p = 0.931). In the group of negative SLN, no 5-year DFS difference was noted between the two groups (p = 0.692). No 5-year DFS and OS difference was noted after propensity-match analysis (87.6% versus 87.0%, p = 0.726 and 97.4% versus 97.9%, p = 0.998, respectively). Conclusion: The use of OSNA as method to exclusively process SLN in cervical cancer was not associated with worse DFS compared to ultrastaging. Incidence of lymph node recurrence in the two groups was not different.
引用
收藏
页数:6
相关论文
共 21 条
[1]   Diagnostic accuracy of sentinel lymph node frozen section analysis in patients with early-stage cervical cancer: A systematic review and meta-analysis [J].
Agusti, Nuria ;
Viveros-Carreno, David ;
Mora-Soto, Nathalia ;
Ramirez, Pedro T. ;
Rauh-Hain, Alejandro ;
Wu, Chi-Fang ;
Rodriguez, Juliana ;
Grillo-Ardila, Carlos Fernando ;
Salazar, Catherin ;
Jorgensen, Kirsten ;
Segarra-Vidal, Blanca ;
Chacon, Enrique ;
Melamed, Alexander ;
Pareja, Rene .
GYNECOLOGIC ONCOLOGY, 2023, 177 :157-164
[2]   Diagnostic value of frozen section examination of sentinel lymph nodes in early-stage cervical cancer at the time of ultrastaging [J].
Balaya, V ;
Guani, B. ;
Benoit, L. ;
Magaud, L. ;
Bonsang-Kitzis, H. ;
Ngo, C. ;
Le Frere-Belda, M. A. ;
Mathevet, P. ;
Lecuru, F. .
GYNECOLOGIC ONCOLOGY, 2020, 158 (03) :576-583
[3]   Role of one-step nucleic acid amplification (OSNA) to detect sentinel lymph node low-volume metastasis in early-stage cervical cancer [J].
Bizzarri, Nicolo ;
Pedone Anchora, Luigi ;
Zannoni, Gian Franco ;
Santoro, Angela ;
Valente, Michele ;
Inzani, Frediano ;
Gallotta, Valerio ;
Conte, Carmine ;
Chiantera, Vito ;
Fanfani, Francesco ;
Fagotti, Anna ;
Ferrandina, Gabriella ;
Scambia, Giovanni .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2020, 30 (03) :364-371
[4]   Sentinel lymph node mapping with indocyanine green in cervical cancer patients undergoing open radical hysterectomy: a single-institution series [J].
Bizzarri, Nicolo ;
Anchora, Luigi Pedone ;
Ferrandina, Gabriella ;
Zannoni, Gian Franco ;
Carbone, Maria Vittoria ;
Fedele, Camilla ;
Teodorico, Elena ;
Gallotta, Valerio ;
Gueli Alletti, Salvatore ;
Chiantera, Vito ;
Fagotti, Anna ;
Scambia, Giovanni ;
Fanfani, Francesco .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2021, 147 (03) :649-659
[5]   Completion of radical hysterectomy does not improve survival of patients with cervical cancer and intraoperatively detected lymph node involvement: ABRAX international retrospective cohort study [J].
Cibula, D. ;
Dostalek, L. ;
Hillemanns, P. ;
Scambia, G. ;
Jarkovsky, J. ;
Persson, J. ;
Raspagliesi, F. ;
Novak, Z. ;
Jaeger, A. ;
Capilna, M. E. ;
Weinberger, V. ;
Klat, J. ;
Schmidt, R. L. ;
Lopez, A. ;
Scibilia, G. ;
Pareja, R. ;
Kucukmetin, A. ;
Kreitner, L. ;
El-Balat, A. ;
Pereira, G. J. R. ;
Laufhutte, S. ;
Isla-Ortiz, D. ;
Toptas, T. ;
Gil-Ibanez, B. ;
Vergote, I. ;
Runnenbaum, I. .
EUROPEAN JOURNAL OF CANCER, 2021, 143 :88-100
[6]   ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer - Update 2023* [J].
Cibula, David ;
Raspollini, Maria Rosaria ;
Planchamp, Francois ;
Centeno, Carlos ;
Chargari, Cyrus ;
Felix, Ana ;
Fischerova, Daniela ;
Jahnn-Kuch, Daniela ;
Joly, Florence ;
Kohler, Christhardt ;
Lax, Sigurd ;
Lorusso, Domenica ;
Mahantshetty, Umesh ;
Mathevet, Patrice ;
Naik, Raj ;
Nout, Remi A. ;
Oaknin, Ana ;
Peccatori, Fedro ;
Persson, Jan ;
Querleu, Denis ;
Bernabe, Sandra Rubio ;
Schmid, Maximilian P. ;
Stepanyan, Artem ;
Svintsitskyi, Valentyn ;
Tamussino, Karl ;
Zapardiel, Ignacio ;
Lindegaard, Jacob .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2023, 33 (05) :649-666
[7]   Sentinel lymph node mapping and intraoperative assessment in a prospective, international, multicentre, observational trial of patients with cervical cancer: The SENTIX trial [J].
Cibula, David ;
Kocian, Roman ;
Plaikner, Andrea ;
Jarkovsky, Jiri ;
Klat, Jaroslav ;
Zapardiel, Ignacio ;
Pilka, Radovan ;
Torne, Aureli ;
Sehnal, Borek ;
Ostojich, Marcela ;
Petiz, Almerinda ;
Sanchez, Octavio A. ;
Presl, Jiri ;
Buda, Alessandro ;
Raspagliesi, Francesco ;
Kascak, Peter ;
van Lonkhuijzen, Luc ;
Barahona, Marc ;
Minar, Lubos ;
Blecharz, Pawel ;
Pakiz, Maja ;
Wydra, Dariusz ;
Snyman, Leon C. ;
Zalewski, Kamil ;
Zorrero, Cristina ;
Havelka, Pavel ;
Redecha, Mikulas ;
Vinnytska, Alla ;
Vergote, Ignace ;
Tingulstad, Solveig ;
Michal, Martin ;
Kipp, Barbara ;
Slama, Jiri ;
Marnitz, Simone ;
Bajsova, Sylva ;
Hernandez, Alicia ;
Fischerova, Daniela ;
Nemejcova, Kristyna ;
Kohler, Christhardt .
EUROPEAN JOURNAL OF CANCER, 2020, 137 :69-80
[8]   Prevention, Screening, Treatment and Follow-Up of Gynecological Cancers: State of Art and Future Perspectives [J].
D'Auge, Tullio Golia ;
Giannini, Andrea ;
Bogani, Giorgio ;
Di Dio, Camilla ;
Lagana, Antonio Simone ;
Di Donato, Violante ;
Salerno, Maria Giovanna ;
Caserta, Donatella ;
Chiantera, Vito ;
Vizza, Enrico ;
Muzii, Ludovico ;
D'Oria, Ottavia .
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 2023, 50 (08)
[9]   Pharmacotherapy for the treatment of recurrent cervical cancer: an update of the literature [J].
D'Oria, Ottavia ;
Bogani, Giorgio ;
Cuccu, Ilaria ;
D'Auge, Tullio Golia ;
Di Donato, Violante ;
Caserta, Donatella ;
Giannini, Andrea .
EXPERT OPINION ON PHARMACOTHERAPY, 2024, 25 (01) :55-65
[10]   Pathologic Protocols for Sentinel Lymph Nodes Ultrastaging in Cervical Cancer [J].
Dundr, Pavel ;
Cibula, David ;
Nemejcova, Kristyna ;
Ticha, Ivana ;
Bartu, Michaela ;
Jaksa, Radek .
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2020, 144 (08) :1011-1020