Reversal of age-associated frailty by controlled physical exercise: The pre-clinical and clinical evidences

被引：13

作者：

Arc-Chagnaud, C. ^{[1
,2
,3
]}

Millan, F. ^{[1
,2
]}

Salvador-Pascual, A. ^{[1
,2
]}

Correas, A. G. ^{[1
,2
]}

Olaso-Gonzalez, G. ^{[1
,2
]}

De la Rosa, A. ^{[1
,2
]}

Carretero, A. ^{[1
,2
]}

Gomez-Cabrera, M. C. ^{[1
,2
]}

Vina, J. ^{[1
,2
]}

机构：

[1] Univ Valencia, Fac Med, Dept Physiol, Freshage Res Grp, Valencia, Spain

[2] Fdn Invest Hosp Clin Univ INCLIVA, CIBERFES, Valencia, Spain

[3] Univ Montpellier, UMR866 Dynam Musculaire & Metab, INRA, F-34060 Montpellier, France

来源：

SPORTS MEDICINE AND HEALTH SCIENCE | 2019年 / 1卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

Sarcopenia; Multicomponent exercise; Disability; Skeletal muscle; Healthy aging; FALL PREVENTION PROGRAM; OLDER-ADULTS; SKELETAL-MUSCLE; PROTEIN-SYNTHESIS; INDEX; STRENGTH; MODEL; INTERVENTIONS; ACCUMULATION; SUPPLEMENT;

D O I：

10.1016/j.smhs.2019.08.007

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

Demographic aging is one of the most serious challenges facing our society. Although we live longer, we do not live better because it is considered that approximately 16-20% of our life is spent in late-life morbidity. Older people have the greatest risk of developing frailty increasing the risk of presenting various adverse health events such as low quality of life, disability, hospitalization and even death. Frail men and women over 65 years old have lower muscle quality and muscle mass and higher percentage of body fat than non-frail people of the same age. In this review we will address the main physiological changes in the muscular and nervous system associated to aging. More specifically we will review the changes in muscle mass, quality, and strength relating them with the decrease in capillarization and muscular oxidative capacity as well as with the alterations in protein synthesis in the muscle with aging. The last section of the manuscript will be devoted to the animal models of frailty and the indexes developed to measure frailty in these models. We will finally address the importance of exercise training as an intervention to delay or even reverse frailty.

引用

页码：33 / 39

页数：7

共 57 条

[1] Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians [J].