Electrochemical E-Selective Semireductive Dicarboxylation of Aryl Alkynes with CO2

被引：12

作者：

Zhao, Lan ^{[1
,2
]}

Xie, Wen-Jun ^{[1
,2
]}

Meng, Zheng-Zheng ^{[1
,2
]}

Li, Hong-Ru ^{[1
,2
,3
]}

He, Liang-Nian ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab, Tianjin 30007, Peoples R China

[2] Nankai Univ, Coll Chem, Inst Elemento Organ Chem, Frontiers Sci Ctr New Organ Matter, Tianjin 30007, Peoples R China

[3] Nankai Univ, Coll Pharm, Tianjin 300350, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 15期

基金：

中国国家自然科学基金;

关键词：

CARBON-DIOXIDE; NICKEL; CARBOXYLATION; ALKENES; ELECTROCARBOXYLATION; REDUCTION;

D O I：

10.1021/acs.orglett.4c00860

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report an electrochemical protocol for the dicarboxylation of aryl alkynes using CO2. With a graphite rod as the cathode and Al as the sacrificial anode, a series of valuable butenedioic acids are obtained in moderate to excellent yields with an E/Z ratio up to 50:1. This method features high E-selectivity, high step and atom economy, easy scalability, and a nice substrate scope, which renders it appealing for promising applications in organic synthesis and materials chemistry.

引用

页码：3241 / 3246

页数：6

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