The impact of levofloxacin prophylaxis on empiric intravenous antibiotic use in pediatric hematopoietic stem cell transplant recipients

被引：0
作者：
Prodanuk, Michael [1 ,2 ,5 ]
Timberlake, Kathryn [3 ]
Koo, Alicia [3 ]
Chopra, Yogi [2 ,4 ]
Wall, Donna A. [2 ,4 ]
Science, Michelle [1 ,2 ]
机构：
[1] Hosp Sick Children, Div Infect Dis, Toronto, ON, Canada
[2] Univ Toronto, Temerty Fac Med, Dept Paediat, Toronto, ON, Canada
[3] Hosp Sick Children, Dept Pharm, Toronto, ON, Canada
[4] Hosp Sick Children, Div Haematol Oncol, Toronto, ON, Canada
[5] Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada
来源：
PEDIATRIC BLOOD & CANCER | 2024年 / 71卷 / 08期
关键词：
antimicrobial stewardship; hematopoietic stem cell transplant; levofloxacin; pediatrics; prophylaxis; CHILDREN;
D O I：
10.1002/pbc.31059
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Levofloxacin prophylaxis during periods of neutropenia in pediatric hematopoietic stem cell transplant (HSCT) may reduce the number of febrile episodes and use of empiric intravenous antibiotics (EIA); however, the literature is conflicting. This retrospective review compared EIA use before and after implementation of levofloxacin prophylaxis at a children's hospital. Levofloxacin prophylaxis was associated with reduced use of certain EIA; however, did not reduce the number of positive blood cultures or clinical deteriorations. Therefore, levofloxacin prophylaxis may have implications for the stewardship of broad-spectrum intravenous antibiotics used in pediatric HSCT.
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页数：4
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