Intestinal remodeling during Xenopus metamorphosis as a model for studying thyroid hormone signaling and adult organogenesis

被引：1

作者：

Shi, Yun-Bo ^{[1
]}

Fu, Liezhen ^{[1
]}

Tanizaki, Yuta ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, Natl Inst Hlth NIH, Sect Mol Morphogenesis, Bethesda, MD 20892 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2024年 / 586卷

关键词：

Thyroid hormone receptor; Programmed cell death; Apoptosis; Stem cell; Metamorphosis; Xenopus laevis; Xenopus tropicalis; Postembryonic development; Intestine; RECEPTOR-MEDIATED TRANSCRIPTION; ARGININE METHYLTRANSFERASE 1; STEM-CELL; C-MYC; EPITHELIAL DEVELOPMENT; NUCLEAR RECEPTOR; GENE-EXPRESSION; IN-VIVO; AMPHIBIAN METAMORPHOSIS; HISTONE ACETYLATION;

D O I：

10.1016/j.mce.2024.112193

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intestinal development takes places in two phases, the initial formation of neonatal (mammals)/larval (anurans) intestine and its subsequent maturation into the adult form. This maturation occurs during postembryonic development when plasma thyroid hormone (T3) level peaks. In anurans such as the highly related Xenopus laevis and Xenopus tropicalis, the larval/tadpole intestine is drastically remodeled from a simple tubular structure to a complex, multi-folded adult organ during T3-dependent metamorphosis. This involved complete degeneration of larval epithelium via programmed cell death and de novo formation of adult epithelium, with concurrent maturation of the muscles and connective tissue. Here, we will summarize our current understanding of the underlying molecular mechanisms, with a focus on more recent genetic and genome-wide studies.

引用

页数：10

共 158 条

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