Prevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis

被引：25

作者：

Feltz-Cornelis, Christina van der ^{[1
,2
,3
,20
]}

Turk, Fidan ^{[1
]}

Sweetman, Jennifer ^{[1
]}

Khunti, Kamlesh ^{[4
]}

Gabbay, Mark ^{[5
]}

Shepherd, Jessie ^{[1
]}

Montgomery, Hugh ^{[6
]}

Strain, W. David ^{[7
,8
]}

Lip, Gregory Y. H. ^{[9
,10
,11
]}

Wootton, Dan ^{[12
,13
,14
]}

Watkins, Caroline Leigh ^{[14
,15
,16
]}

Cuthbertson, Daniel J. ^{[16
,17
]}

Williams, Nefyn ^{[5
]}

Banerjee, Amitava ^{[3
,18
,19
]}

机构：

[1] Univ York, Dept Hlth Sci, York, England

[2] Univ York, Hull York Med Sch HYMS, York, England

[3] UCL, Inst Hlth Informat, London, England

[4] Univ Leicester, Diabet Res Ctr, Leicester, England

[5] Univ Liverpool, Dept Primary Care & Mental Hlth, Liverpool, England

[6] UCL, Dept Med, London, England

[7] Univ Exeter, Inst Clin & Biomed Sci, Diabet & Vasc Med Res Ctr, Exeter, England

[8] Univ Exeter, Coll Med & Hlth, Exeter, England

[9] Liverpool John Moores Univ, Liverpool Ctr Cardiovasc Sci, Univ Liverpool, Liverpool, England

[10] Liverpool Heart & Chest Hosp, Liverpool, England

[11] Aalborg Univ, Danish Ctr Hlth Serv Res, Dept Clin Med, Aalborg, Denmark

[12] Univ Liverpool, Inst Infect Vet & Ecol Sci, Liverpool, England

[13] Univ Liverpool, NIHR HPRU Emerging & Zoonot Infect, Liverpool, England

[14] Liverpool Univ Hosp NHS Fdn Trust, Liverpool, England

[15] Univ Cent Lancashire, Lancashire Clin Trials Unit, Preston, England

[16] Univ Cent Lancashire, Sch Nursing & Midwifery, Preston, England

[17] Univ Liverpool, Inst Cardiovasc & Metab Med, Liverpool, England

[18] Univ Coll London Hosp NHS Trust, Dept Cardiol, London, England

[19] Barts Hlth NHS Trust, Dept Cardiol, London, England

[20] Univ York, Dept Hlth Sci, HYMS, ARRC Bldg T204, York, England

来源：

GENERAL HOSPITAL PSYCHIATRY | 2024年 / 88卷

关键词：

Long COVID; Mental health conditions; Brain fog; COVID-19; SARS-CoV-2; Meta; -analysis; DEPRESSION; DISORDER;

D O I：

10.1016/j.genhosppsych.2024.02.009

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Long COVID can include impaired cognition ('brain fog'; a term encompassing multiple symptoms) and mental health conditions. We performed a systematic review and meta-analysis to estimate their prevalence and to explore relevant factors associated with the incidence of impaired cognition and mental health conditions. Methods: Searches were conducted in Medline and PsycINFO to cover the start of the pandemic until August 2023. Included studies reported prevalence of mental health conditions and brain fog in adults with long COVID after clinically-diagnosed or PCR-confirmed SARS-CoV-2 infection. Findings: 17 studies were included, reporting 41,249 long COVID patients. Across all timepoints (3-24 months), the combined prevalence of mental health conditions and brain fog was 20.4% (95% CI 11.1%-34.4%), being lower among those previously hospitalised than in community-managed patients(19.5 vs 29.7% respectively; p = 0.047). The odds of mental health conditions and brain fog increased over time and when validated instruments were used. Odds of brain fog significantly decreased with increasing vaccination rates (p = .000). Conclusions: Given the increasing prevalence of mental health conditions and brain fog over time, preventive interventions and treatments are needed. Research is needed to explore underlying mechanisms that could inform further research in development of effective treatments. The reduced risk of brain fog associated with vaccination emphasizes the need for ongoing vaccination programs.

引用

页码：10 / 22

页数：13