3D printing of polylactic acid/poly ethylene glycol/hydroxyapatite porous bone scaffolds and their biocompatibility

被引：0
|
作者：
Fan Z.-W. [1 ]
Zhao X.-Y. [1 ]
Qiu S. [1 ]
Wang Y. [1 ]
Guo J. [1 ]
Quan H.-X. [2 ]
Xu L.-J. [3 ]
机构：
[1] School of Textile and Material Engineering, Dalian Polytechnic University, Dalian
[2] First Affiliated Hospital of Dalian Medical University, Dalian
[3] Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou
来源：
Cailiao Gongcheng/Journal of Materials Engineering | 2021年 / 49卷 / 04期
关键词：
3D printing; Biocompatibility; Polylactic acid; Porous scaffold;
D O I：
10.11868/j.issn.1001-4381.2020.000390
中图分类号：
学科分类号：
摘要：
Polylactic acid (PLA) is a widely used biopolymer material. However, there are disadvantages such as poor toughness, poor hydrophilicity, and poor biological activity in the application process. It was modified with polyethylene glycol (PEG) and hydroxyapatite (HA).3D printing filaments of PLA/PEG/HA with different mass ratios were prepared by melt blending. And by analyzing the mechanical properties, crystallization properties, thermal properties, rheological properties of PLA/PEG/HA filaments, the more suitable filaments for fused deposition modeling of 3D printing (FDM) were screened, and then the high precision mechanical samples and bioporous scaffolds with good biocompatibility, cell value-added and differentiation were 3D printed. The results show that the addition of PEG improves the toughness of PLA and lowers the melting point of PLA. The addition of HA increases the elastic modulus and cold crystallization temperature of PLA/PEG/HA composites, and HA can also improve the flowability of PLA/PEG/HA composites. SEM and fluorescent labeling results show that the porous scaffold has good biocompatibility. The successful cultivation of bioscaffolds in vitro cells provides potential for further exploration of bioporous scaffolds in animals, biomedicine, and customized applications. © 2021, Journal of Materials Engineering. All right reserved.
引用
收藏
页码：135 / 141
页数：6
相关论文
共 18 条
  • [1] ZHANG P S, XIN Y, CAO C L, Et al., Preparation and properties of polycaprolactone porous bone scaffold modified with chitosan/hydroxyapatite on the surface, Journal of Materials Engineering, 47, 7, pp. 64-70, (2019)
  • [2] SHEN S., Construction and osteogenesis capacity study of biomimetic poly(L-lactic acid) nanofiber bone tissue engineering scaffolds, (2018)
  • [3] SHU H J, WU C X, YANG K, Et al., Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function, Journal of Materials Engineering, 47, 12, pp. 124-129, (2019)
  • [4] SINGH O P, AHMED S M, ABHILASH M., Modern 3D printing technologies: future trends and developments, Recent Patents on Engineering, 9, 2, pp. 91-103, (2015)
  • [5] WEI Z C, CAI C Y, WANG X, Et al., Research progress on toughening polylactic acid by renewable and biodegradable polymers, Journal of Materials Engineering, 47, 5, pp. 34-42, (2019)
  • [6] BHASKAR B, OWEN R, BAHMAEE H, Et al., Composite porous scaffold of polyethylene glycol (PEG)/polylactic acid (PLA) support improved bone matrix deposition in vitro compared to PLA -only scaffolds, Journal of Biomedical Materials Research: Part A, 106, 5, pp. 1-23, (2018)
  • [7] ROSENZEWIG H R, CARELLI E, STEFFEN T, Et al., 3D-printed ABS and PLA scaffolds for cartilage and nucleus pulposus tissue regeneration, International Journal of Molecular Sciences, 16, 7, pp. 15119-15135, (2015)
  • [8] TIZIANO S, MONICA O H, ELISABETH E, Et al., Relevance of PEG in PLA-based blends for tissue engineering 3D-printed scaffolds, Materials Science Engineering C, 38, 1, pp. 55-62, (2014)
  • [9] MEUNIER M, GOUPIL A, LIENARD P., Predicting drug loading in PLA-PEG nanoparticles, International Journal of Pharmaceutics, 526, 1, pp. 157-166, (2017)
  • [10] WANG F, HU Y, HE D, Et al., Scaffold-free cartilage cell sheet combined with bone-phase BMSCs-scaffold regenerate osteochondral construct in mini-pig model, American Journal of Translational Research, 10, 10, pp. 2997-3010, (2018)
12