Complete response in patient with locally advanced lung large cell neuroendocrine carcinoma under sintilimab plus platinum-based chemotherapy: A case report

被引：1

作者：

Huang, Jinpeng ^{[1
,2
]}

Wang, Feiye ^{[3
]}

Du, Xiaohua ^{[4
]}

Li, Yongfeng ^{[5
]}

Zhuang, Yuanyuan ^{[1
,2
]}

Gan, Ziyan ^{[1
,2
]}

Long, Shunqin ^{[1
,2
]}

Wu, Wanyin ^{[1
,2
]}

Yang, Xiaobing ^{[1
,2
]}

机构：

[1] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China

[2] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Clin Med Coll 2, Oncol Dept, Guangzhou, Peoples R China

[3] China Acad Chinese Med Sci, Xiyuan Hosp, Dept Oncol, Beijing, Peoples R China

[4] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Clin Med Coll 2, Pathol Dept, Guangzhou, Peoples R China

[5] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Clin Med Coll 2, Thorac Surg Dept, Guangzhou, Peoples R China

来源：

HELIYON | 2024年 / 10卷 / 05期

关键词：

Lung large -cell carcinoma; PD-1; inhibitor; Chemotherapy; Complete response; Case report; CANCER; TUMORS; NIVOLUMAB; EFFICACY; IMPACT;

D O I：

10.1016/j.heliyon.2024.e27105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is an uncommon subtype of lung cancer with bleak prognosis. Its optimal treatment remains undetermined due to its malignancy. A 66year-old man diagnosed with unresectable locally advanced LCNEC exhibited partial radiographic response to chemo-immunotherapy. He underwent salvage surgery after 4 rounds of docetaxel/nedaplatin (DP) regimen plus sintilimab, a highly selective monoclonal antibody which targets human anti-programmed death-ligand 1 (PD-L1). In addition, the pathologic examination of the excision demonstrated that there were no viable residuary tumor cells. This case indicates that neoadjuvant chemo-immunotherapy might benefit patients with locally advanced LCNEC, which deserves further investigation.

引用

页数：6

共 20 条

[1] Neuroendocrine neoplasms of the lung: A prognostic spectrum [J].

Asamura, H ;

Kameya, T ;

Matsuno, Y ;

Noguchi, M ;

Tada, H ;

Ishikawa, Y ;

Yokose, T ;

Jiang, SX ;

Inoue, T ;

Nakagawa, K ;

Tajima, K ;

Nagai, K .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (01) :70-76

[2] Large cell neuroendocrine carcinoma: An aggressive form of non-small cell lung cancer [J].

Battafarano, RJ ;

Fernandez, FG ;

Ritter, J ;

Meyers, BF ;

Guthrie, TJ ;

Cooper, JD ;

Patterson, GA .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2005, 130 (01) :166-172

[3] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[4] Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids [J].

Caplin, M. E. ;

Baudin, E. ;

Ferolla, P. ;

Filosso, P. ;

Garcia-Yuste, M. ;

Lim, E. ;

Oberg, K. ;

Pelosi, G. ;

Perren, A. ;

Rossi, R. E. ;

Travis, W. D. .

ANNALS OF ONCOLOGY, 2015, 26 (08) :1604-1620

[5] Clinical features of large cell neuroendocrine carcinoma: a population-based overview [J].

Derks, Jules L. ;

Hendriks, Lizza E. ;

Buikhuisen, Wieneke A. ;

Groen, Harry J. M. ;

Thunnissen, Erik ;

van Suylen, Robert-Jan ;

Houben, Ruud ;

Damhuis, Ronald A. ;

Speel, Ernst J. M. ;

Dingemans, Anne-Marie C. .

EUROPEAN RESPIRATORY JOURNAL, 2016, 47 (02) :615-624

[6] Large cell/neuroendocrine carcinoma [J].

Gollard, Russell ;

Jhatakia, Sejal ;

Elliott, Max ;

Kosty, Michael .

LUNG CANCER, 2010, 69 (01) :13-18

[7] Bronchopulmonary neuroendocrine tumors [J].

Gustafsson, Bjorn I. ;

Kidd, Mark ;

Chan, Anthony ;

Malfertheiner, Max V. ;

Modlin, Irvin M. .

CANCER, 2008, 113 (01) :5-21

[8] Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial [J].

Herbst, Roy S. ;

Baas, Paul ;

Kim, Dong-Wan ;

Felip, Enriqueta ;

Perez-Gracia, Jose L. ;

Han, Ji-Youn ;

Molina, Julian ;

Kim, Joo-Hang ;

Arvis, Catherine Dubos ;

Ahn, Myung-Ju ;

Majem, Margarita ;

Fidler, Mary J. ;

de Castro, Gilberto, Jr. ;

Garrido, Marcelo ;

Lubiniecki, Gregory M. ;

Shentu, Yue ;

Im, Ellie ;

Dolled-Filhart, Marisa ;

Garon, Edward B. .

LANCET, 2016, 387 (10027) :1540-1550

[9] Prognostic impact of large cell neuroendocrine histology in patients with pathologic stage Ia pulmonary non-small cell carcinoma [J].

Iyoda, Akira ;

Hiroshima, Kenzo ;

Moriya, Yasumitsu ;

Sekine, Yasuo ;

Shibuya, Kiyoshi ;

Iizasa, Toshihiko ;

Nakatani, Yukio ;

Fujisawa, Takehiko .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2006, 132 (02) :312-315

[10] Factors associated with treatment receipt and overall survival for patients with locally advanced large cell neuroendocrine carcinoma of the lung: A National Cancer Database analysis [J].

Limonnik, Vladimir ;

Abel, Stephen ;

Finley, Gene G. ;

Long, Gregory S. ;

Wegner, Rodney E. .

LUNG CANCER, 2020, 150 :107-113

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