DESIGN OF JACKFRUIT GUM-BASED GENIPIN CROSSLINKED NANOPARTICLES FOR SUSTAINED RELEASE OF CURCUMIN: OPTIMIZATION AND IN VITRO CHARACTERIZATION

被引：0

作者：

Thakare, Swapnil ^{[1
]}

Gorle, Ashish ^{[1
]}

机构：

[1] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut, Shirpur 425405, Maharashtra, India

来源：

CELLULOSE CHEMISTRY AND TECHNOLOGY | 2024年 / 58卷 / 1-2期

关键词：

jackfruit gum; genipin; ionotropic gelation; curcumin; nanoparticles; sustained release; DELIVERY; MUCOADHESIVE; MANAGEMENT; BEHAVIOR; CANCER;

D O I：

10.35812/CelluloseChemTechnol.2024.58.07

中图分类号：

TB3 [工程材料学]; TS [轻工业、手工业、生活服务业];

学科分类号：

0805 ; 080502 ; 0822 ;

摘要：

The present work aims to design jackfruit gum-based curcumin-loaded nanoparticles (CUR-NPs) for improved drug entrapment and modified release of CUR using ionotropic gelation. Briefly, the optimization of CUR-NPs was confirmed using a 32 response surface methodology. The diffractogram and thermogram of CUR-NPs confirmed reduction of crystallinity of CUR (optimized batch: F5) due to jackfruit gum and genipin cross-linked polymeric network. The particle size and zeta potential analysis confirmed formation of nanosized and stable CUR-NPs, respectively. Also, the nanoparticles demonstrated 83.99 +/- 1.23% entrapment efficiency, whereas they showed 98.36 +/- 0.96% of CUR release within 12 h at pH 7.4. The CUR-NPs exhibited good mucoadhesive properties due to the presence of jackfruit gum. Finally, the MTT assay showed a decrease in colorectal cancer cell viability due to tailored CUR release from CUR-NPs. In conclusion, jackfruit gum-genipin-based CUR-NPs offered high entrapment efficiency, tailored releases of CUR, good mucoadhesive property and improved anticancer activity.

引用

页码：67 / 79

页数：13

共 28 条

[1] Recent advances on chitosan-based micro- and nanoparticles in drug delivery [J].

Agnihotri, SA ;

Mallikarjuna, NN ;

Aminabhavi, TM .

JOURNAL OF CONTROLLED RELEASE, 2004, 100 (01) :5-28

[2] Are cancer cells really softer than normal cells? [J].

Alibert, Charlotte ;

Goud, Bruno ;

Manneville, Jean-Baptiste .

BIOLOGY OF THE CELL, 2017, 109 (05) :167-189

[3]

Biswas M, 2001, ADV POLYM SCI, V155, P167

[4] Design of polyacrylamide grafted sesbania gum-mediated pH-responsive IPN-based microbeads for delivery of diclofenac sodium: In-vitro-in-vivo characterizations [J].

Devkar, Pratiksha ;

Nangare, Sopan ;

Zawar, Laxmikant ;

Shirsath, Nitin ;

Bafna, Piyush ;

Jain, Pankaj .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 230

[5] Dissolution behavior of 13-cyclodextrin molecular inclusion complexes of aceclofenac [J].

Dua, Kamal ;

Pabreja, Kavita ;

Ramana, M. V. ;

Lather, Vinny .

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2011, 3 (03) :417-425

[6] Who gets chemotherapy for metastatic lung cancer? [J].

Earle, CC ;

Venditti, LN ;

Neumann, PJ ;

Gelber, RD ;

Weinstein, MC ;

Potosky, AL ;

Weeks, JC .

CHEST, 2000, 117 (05) :1239-1246

[7] Toxic effects and their management: daily clinical challenges in the treatment of colorectal cancer [J].

Eng, Cathy .

NATURE REVIEWS CLINICAL ONCOLOGY, 2009, 6 (04) :207-218

[8] cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo [J].

Gu, Xiaolei ;

Wei, Yaohua ;

Fan, Qianyi ;

Sun, Huanli ;

Cheng, Ru ;

Zhong, Zhiyuan ;

Deng, Chao .

JOURNAL OF CONTROLLED RELEASE, 2019, 301 :110-118

[9] World Health Organization call for action to eliminate cervical cancer globally [J].

Gultekin, Murat ;

Ramirez, Pedro T. ;

Broutet, Nathalie ;

Hutubessy, Raymond .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2020, 30 (04) :426-427

[10] Genipin crosslinked curcumin loaded chitosan/montmorillonite K-10 (MMT) nanoparticles for controlled drug delivery applications [J].

Khatun, Bably ;

Banik, Nibedita ;

Hussain, Anowar ;

Ramteke, Anand ;

Maji, Tarun .

JOURNAL OF MICROENCAPSULATION, 2018, 35 (05) :439-453

← 1 2 3 →