Iodine-catalyzed intermolecular 1,2-thio (seleno)amination of alkenes with 1,2,3-triazoles and disulfides (diselenides) in air

被引：3

作者：

Ji, Jian ^{[1
]}

Chen, Xuwen ^{[1
]}

Hu, Zongjing ^{[1
]}

Guan, Cong ^{[1
]}

Liu, Jinhua ^{[1
]}

Deng, Yaqi ^{[1
]}

Liu, Shunying ^{[1
]}

机构：

[1] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 11期

基金：

中国国家自然科学基金;

关键词：

REDUCTION; CHLORIDES; AMMONIA;

D O I：

10.1039/d4qo00246f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iodine-catalyzed direct radical coupling method for 1,2-thio (seleno)amination of alkenes with 1,2,3-triazoles and disulfides (diselenides) in air was developed. Products were constructed in one pot with high chemoselectivity and regioselectivity as well as a wide range of substrate scopes (including terminal and internal alkenes). Preliminary mechanistic studies indicated that formation of the C-N bond proceeded via a desulfonation-associated tandem radical cross-coupling process. Iodine-catalyzed 1,2-thio (seleno)amination of alkenes via direct N- and C-centered radical cross-coupling was established to elicit highly regioselective beta-triazolized thioalkyl compounds.

引用

页码：3066 / 3071

页数：6