Developmental Toxicity of Fine Particulate Matter: Multifaceted Exploration from Epidemiological and Laboratory Perspectives

被引:3
作者
Yan, Ruifeng [1 ]
Ma, Danni [1 ]
Liu, Yutong [1 ]
Wang, Rui [1 ]
Fan, Lifan [1 ]
Yan, Qiqi [1 ]
Chen, Chen [1 ]
Wang, Wenhao [1 ]
Ren, Zhihua [1 ]
Ku, Tingting [1 ]
Ning, Xia [1 ]
Sang, Nan [1 ]
机构
[1] Shanxi Univ, Coll Environm & Resource, Res Ctr Environm & Hlth, Taiyuan 030006, Peoples R China
基金
美国国家科学基金会; 国家重点研发计划;
关键词
fine particulate matter; adverse birth outcomes; respiratory development; cardiovascular development; neurological development; mechanism; AMBIENT AIR-POLLUTION; PM2.5; EXPOSURE; MATERNAL EXPOSURE; PRENATAL EXPOSURE; BIRTH-DEFECTS; SAO-PAULO; AUTISM; NEUROTOXICITY; PREGNANCY; MICROGLIA;
D O I
10.3390/toxics12040274
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Particulate matter of size <= 2.5 mu m (PM2.5) is a critical environmental threat that considerably contributes to the global disease burden. However, accompanied by the rapid research progress in this field, the existing research on developmental toxicity is still constrained by limited data sources, varying quality, and insufficient in-depth mechanistic analysis. This review includes the currently available epidemiological and laboratory evidence and comprehensively characterizes the adverse effects of PM2.5 on developing individuals in different regions and various pollution sources. In addition, this review explores the effect of PM2.5 exposure to individuals of different ethnicities, genders, and socioeconomic levels on adverse birth outcomes and cardiopulmonary and neurological development. Furthermore, the molecular mechanisms involved in the adverse health effects of PM2.5 primarily encompass transcriptional and translational regulation, oxidative stress, inflammatory response, and epigenetic modulation. The primary findings and novel perspectives regarding the association between public health and PM2.5 were examined, highlighting the need for future studies to explore its sources, composition, and sex-specific effects. Additionally, further research is required to delve deeper into the more intricate underlying mechanisms to effectively prevent or mitigate the harmful effects of air pollution on human health.
引用
收藏
页数:25
相关论文
共 106 条
[1]   Air pollution and congenital heart defects [J].
Agay-Shay, Keren ;
Friger, Michael ;
Linn, Shai ;
Peled, Ammatzia ;
Amitai, Yona ;
Peretz, Chava .
ENVIRONMENTAL RESEARCH, 2013, 124 :28-34
[2]   Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: Parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders [J].
Allen, J. L. ;
Oberdorster, G. ;
Morris-Schaffer, K. ;
Wong, C. ;
Klocke, C. ;
Sobolewski, M. ;
Conrad, K. ;
Mayer-Proschel, M. ;
Cory-Slechta, D. A. .
NEUROTOXICOLOGY, 2017, 59 :140-154
[3]   Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution: Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in Male Mice [J].
Allen, Joshua L. ;
Liu, Xiufang ;
Pelkowski, Sean ;
Palmer, Brian ;
Conrad, Katherine ;
Oberdoerster, Guenter ;
Weston, Douglas ;
Mayer-Proschel, Margot ;
Cory-Slechta, Deborah A. .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2014, 122 (09) :939-945
[4]   Developmental Exposure to Concentrated Ambient Ultrafine Particulate Matter Air Pollution in Mice Results in Persistent and Sex-Dependent Behavioral Neurotoxicity and Glial Activation [J].
Allen, Joshua L. ;
Liu, Xiufang ;
Weston, Douglas ;
Prince, Lisa ;
Oberdoerster, Guenter ;
Finkelstein, Jacob N. ;
Johnston, Carl J. ;
Cory-Slechta, Deborah A. .
TOXICOLOGICAL SCIENCES, 2014, 140 (01) :160-178
[5]   Microglia toxicity in preterm brain injury [J].
Baburamani, Ana A. ;
Supramaniam, Veena G. ;
Hagberg, Henrik ;
Mallard, Carina .
REPRODUCTIVE TOXICOLOGY, 2014, 48 :106-112
[6]   Air pollution: mechanisms of neuroinflammation and CNS disease [J].
Block, Michelle L. ;
Calderon-Garciduenas, Lilian .
TRENDS IN NEUROSCIENCES, 2009, 32 (09) :506-516
[7]   Association of developmental coordination disorder with early-life exposure to fine particulate matter in Chinese preschoolers [J].
Cai, Jing ;
Shen, Yang ;
Meng, Xia ;
Zhao, Yan ;
Niu, Yue ;
Chen, Renjie ;
Du, Wenchong ;
Quan, Guangbin ;
Barnett, Anna L. ;
Jones, Gary ;
Kan, Haidong ;
Hua, Jing .
INNOVATION, 2023, 4 (01)
[8]   Maternal exposure to aircraft emitted ultrafine particles during pregnancy and likelihood of ASD in children [J].
Carter, Sarah A. ;
Rahman, Md Mostafijur ;
Lin, Jane C. ;
Chow, Ting ;
Yu, Xin ;
Martinez, Mayra P. ;
Levitt, Pat ;
Chen, Zhanghua ;
Chen, Jiu-Chiuan ;
Eckel, Sandrah P. ;
Schwartz, Joel ;
Lurmann, Frederick W. ;
Kleeman, Michael J. ;
McConnell, Rob ;
Xiang, Anny H. .
ENVIRONMENT INTERNATIONAL, 2023, 178
[9]   Advances in epigenetics link genetics to the environment and disease [J].
Cavalli, Giacomo ;
Heard, Edith .
NATURE, 2019, 571 (7766) :489-499
[10]   PM2.5 induces mitochondrial dysfunction via AHR-mediated cyp1a1 overexpression during zebrafish heart development [J].
Chen, Jin ;
Zhang, Mingxuan ;
Zou, Hongmei ;
Aniagu, Stanley ;
Jiang, Yan ;
Chen, Tao .
TOXICOLOGY, 2023, 487