MASLD-Related HCC-Update on Pathogenesis and Current Treatment Options

被引：11

作者：

Leyh, Catherine ^{[1
]}

Coombes, Jason D. ^{[2
]}

Schmidt, Hartmut H. ^{[3
]}

Canbay, Ali ^{[4
]}

Manka, Paul P. ^{[4
]}

Best, Jan ^{[3
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Dept Gastroenterol Hepatol & Infect Dis, Univ Hosp Dusseldorf, Med Fac, D-40225 Dusseldorf, Germany

[2] St Louis Univ, Div Gastroenterol & Hepatol, Internal Med, Sch Med, St Louis, MO 63104 USA

[3] Univ Duisburg Essen, Med Fac, Dept Gastroenterol Hepatol & Transplant Med, D-45147 Essen, Germany

[4] Ruhr Univ Bochum, Univ Hosp Knappschaftskrankenhaus Bochum, Dept Internal Med, D-44801 Bochum, Germany

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2024年 / 14卷 / 04期

关键词：

hepatocellular carcinoma; HCC; MASLD; MASH; NAFLD; NASH; biomarker; intestinal microbiota; FATTY LIVER-DISEASE; UNRESECTABLE HEPATOCELLULAR-CARCINOMA; ATEZOLIZUMAB PLUS BEVACIZUMAB; TRANSPLANTATION; SORAFENIB; CANCER; OBESITY; RISK; CABOZANTINIB; METAANALYSIS;

D O I：

10.3390/jpm14040370

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Hepatocellular carcinoma (HCC) is a common complication of chronic liver diseases and remains a relevant cause of cancer-related mortality worldwide. The global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) as a risk factor for hepatocarcinogenesis is on the rise. Early detection of HCC has been crucial in improving the survival outcomes of patients with metabolic dysfunction-associated steatohepatitis (MASH), even in the absence of cirrhosis. Understanding how hepatocarcinogenesis develops in MASH is increasingly becoming a current research focus. Additive risk factors such as type 2 diabetes mellitus (T2DM), genetic polymorphisms, and intestinal microbiota may have specific impacts. Pathophysiological and epidemiological associations between MASH and HCC will be discussed in this review. We will additionally review the available tumor therapies concerning their efficacy in MASH-associated HCC treatment.

引用

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