Three-Component Heterocyclization of 5-(Arylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-triones with Isoquinoline and Dimethyl But-2-ynedioate

被引：0

作者：

Tyrkov, A. G. ^{[1
]}

Yurtaeva, E. A. ^{[2
]}

机构：

[1] Tatishchev Astrakhan State Univ, Astrakhan 414056, Russia

[2] Branch Volgograd State Med Univ, Minist Hlth Russian Federat, Pyatigorsk Med & Pharmaceut Inst, Pyatigorsk 357532, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 04期

关键词：

5-(arylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones; isoquinoline; dimethyl but-2-ynedioate; three-component heterocyclization; dimethyl 2-aryl-2 ',4 ',6 '-trioxo-1 ',3 ',4 ',6 '-tetrahydro-2H,2 ' H,11bH-spiro[pyrido[2,1-a]isoquinoline-1,5 '-pyrimidine]-3,4-dicarboxylates; dipotassium 2-aryl-2 ',4 ',6 '-trioxo-1 ',3 ',4 ',6 '-tetrahydro-2H,2 ' H,11bH-spiro[pyrido[2,1-a]isoquinoline-1,5 '-pyrimidine]-3,4-dicarboxylates; 5-(ARYLMETHYLIDENE)-2,4,6-PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONES;

D O I：

10.1134/S1070428024040122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction 5-(arylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones with isoquinoline and dimethyl but-2-ynedioate gave cycloaddition products, mixtures of diastereoisomeric substituted dimethyl 2-aryl-2 ',4 ',6 '-trioxo-1 ',3 ',4 ',6 '-tetrahydro-2H,2 ' H,11bH-spiro[pyrido[2,1-a]isoquinoline-1,5 '-pyrimidine]-3,4-dicarboxylates which were converted to the corresponding dipotassium salts by treatment with excess potassium hydroxide in ethanol. The synthesized compounds are of interest as promising intermediate products with potential antitubercular and fungicidal activities.

引用

页码：645 / 649

页数：5