Cytokines and chemokines in patients with chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy: A systematic review

被引:2
作者
Cutelle, Claudia [1 ]
De Lorenzo, Alberto [2 ]
Doneddu, Pietro Emiliano [1 ,3 ]
Creta, Maria Francesca [2 ]
Selmi, Carlo [4 ]
Liberatore, Giuseppe [1 ]
Giordano, Andrea [2 ]
Gentile, Francesco [2 ]
Erre, Gian Luca [5 ]
Nobile-Orazio, Eduardo [1 ,6 ]
机构
[1] IRCCS Humanitas Res Hosp, Neuromuscular & Neuroimmunol Unit, Via Manzoni 56, I-20089 Milan, Italy
[2] Milan Univ, Neurol Residency Program, Milan, Italy
[3] Humanitas Univ, Dept Biomed Sci, Milan, Italy
[4] IRCCS Humanitas Res Hosp, Div Rheumatol & Clin Immunol, Milan, Italy
[5] Sassari Univ, Dept Med Surg & Pharm, Sassari, Italy
[6] Milan Univ, Dept Med Biotechnol & Translat Med, Milan, Italy
关键词
biomarker; chronic inflammatory demyelinating polyradiculoneuropathy; cytokines; multifocal motor neuropathy; GUILLAIN-BARRE-SYNDROME; NECROSIS-FACTOR-ALPHA; CEREBROSPINAL-FLUID; TNF-ALPHA; INTRAVENOUS IMMUNOGLOBULIN; SYNOVIAL-FLUID; SERUM-LEVELS; PROINFLAMMATORY CYTOKINES; RHEUMATOID-ARTHRITIS; PERIPHERAL-BLOOD;
D O I
10.1111/jns.12622
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Advances in the understanding of cytokines have revolutionized mechanistic treatments for chronic inflammatory and autoimmune diseases, as exemplified by rheumatoid arthritis. We conducted a systematic literature review on the role of cytokines and chemokines in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN). Ovid Medline, EMBASE and Web of Science were searched until August 31, 2022 for human studies investigating cytokines levels in CIDP or MMN. Fifty-five articles on 1061 CIDP patients and 86 MMN patients were included, with a median of 18 patients per study (range 3-71). Studies differed in the inclusion criteria, type of assay, manufacturer, control subjects, and tested biological material. Only a minority of studies reported data on disease activity. Interleukin (IL)-6, IL-17, CXCL10, and tumor necrosis factor alpha (TNF-alpha), were elevated in CIDP compared to controls in most of the studies. IL-6 and TNF-alpha levels are also correlated with disability. In MMN patients, IL-1Ra was elevated in the majority of the reports. While acknowledging the challenges in comparing studies and the various limitations of the studies, including small patient numbers, particularly in MMN, our review suggests that IL-6, IL-17, CXCL10, and TNF-alpha might play a role in CIDP pathogenesis. Larger studies are needed in MMN.
引用
收藏
页码:124 / 134
页数:11
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