Off-label Use of Long-Acting Injectable Antiretroviral Therapy: A Single Center Retrospective Review of Youth Living With HIV With Detectable HIV RNA Starting Injectable Therapy

被引:5
作者
Rousseau, Alison [1 ]
McGrath, Eric [2 ]
Benjamins, Laura [3 ]
Cockern, Salome [4 ]
Meade, Jill [4 ]
Houston, Keshaum [4 ]
Breaux, Melina [4 ]
Secord, Elizabeth [5 ]
机构
[1] Wayne State Univ, Sch Med WSUSOM, Detroit, MI USA
[2] Div Pediat Infect Dis, WSUSOM, Detroit, MI USA
[3] Div Adolescent Med, WSUSOM, Detroit, MI USA
[4] Dept Pediat, WSUSOM, Detroit, MI USA
[5] Div Chief Allergy & Immunol, WSUSOM, Wayne Pediat 400 Mack Ave, Detroit, MI 48201 USA
关键词
adherence; HIV; HIV plus youth; injectable antiretrovirals; perinatal; RILPIVIRINE; ADOLESCENTS; ADHERENCE; ADULTS;
D O I
10.1093/jpids/piae033
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Nineteen youth living with HIV (YLWH) opted for injectable cabotegravir and rilpivirine without oral lead in and without achieving an undetectable HIV viral load (VL) for the 3 months prior to initiation. All achieved undetectable status within 3 months (3 injections) and maintained an undetectable status through 6-12 months of therapy. Nineteen youth living with HIV (YLWH) started injectable cabotegravir and rilpivirine without oral lead in and without achieving an undetectable HIV VL for the 3 months prior to initiation. All achieved undetectable status within 3 months (3 injections) maintaining undetectable status 6-12 months into therapy.
引用
收藏
页码:285 / 287
页数:3
相关论文
共 12 条
[1]   Rare case of rilpivirine-induced severe allergic hepatitis [J].
Ahmed, Yasir ;
Siddiqui, Wajid ;
Enoch, Caroline B. ;
Albrecht, Helmut ;
Bookstaver, P. Brandon .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2013, 68 (02) :484-486
[2]   Randomized Controlled Trial of a Remote Coaching mHealth Adherence Intervention in Youth Living with HIV [J].
Amico, K. Rivet ;
Lindsey, Jane C. ;
Hudgens, Michael ;
Dallas, Ronald ;
Horvath, Keith J. ;
Dunlap, Amanda ;
Goolsby, Rachel ;
Johnson, Megan Mueller ;
Heckman, Barbara ;
Crawford, Jessica ;
Secord, Elizabeth ;
Purswani, Murli ;
Reirden, Danial ;
Rathore, Mobeen ;
Robinson, Lisa-Gaye ;
Gaur, Aditya H. .
AIDS AND BEHAVIOR, 2022, 26 (12) :3897-3913
[3]  
[Anonymous], Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents
[4]   Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir plus rilpivirine (LATTE-2) in the United States and Spain [J].
Kerrigan, Deanna ;
Mantsios, Andrea ;
Gorgolas, Miguel ;
Montes, Maria-Luisa ;
Pulido, Federico ;
Brinson, Cynthia ;
deVente, Jerome ;
Richmond, Gary J. ;
Beckmam, Sarah W. ;
Hammond, Paige ;
Margolis, David ;
Murray, Miranda .
PLOS ONE, 2018, 13 (01)
[5]  
Casado JL, 2013, AIDS REV, V15, P139
[6]   Medication Adherence in Children and Adolescents with HIV Infection: Associations with Behavioral Impairment [J].
Malee, Kathleen ;
Williams, Paige ;
Montepiedra, Grace ;
McCabe, Marie ;
Nichols, Sharon ;
Sirois, Patricia A. ;
Storm, Deborah ;
Farley, John ;
Kammerer, Betsy .
AIDS PATIENT CARE AND STDS, 2011, 25 (03) :191-200
[7]   Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial [J].
Margolis, David A. ;
Gonzalez-Garcia, Juan ;
Stellbrink, Hans-Juergen ;
Eron, Joseph J. ;
Yazdanpanah, Yazdan ;
Podzamczer, Daniel ;
Lutz, Thomas ;
Angel, Jonathan B. ;
Richmond, Gary J. ;
Clotet, Bonaventura ;
Gutierrez, Felix ;
Sloan, Louis ;
St Clair, Marty ;
Murray, Miranda ;
Ford, Susan L. ;
Mrus, Joseph ;
Patel, Parul ;
Crauwels, Herta ;
Griffith, Sandy K. ;
Sutton, Kenneth C. ;
Dorey, David ;
Smith, Kimberly Y. ;
Williams, Peter E. ;
Spreen, William R. .
LANCET, 2017, 390 (10101) :1499-1510
[8]  
Moore CB., CROI 2022
[9]   Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study [J].
Overton, Edgar T. ;
Richmond, Gary ;
Rizzardini, Giuliano ;
Jaeger, Hans ;
Orrell, Catherine ;
Nagimova, Firaya ;
Bredeek, Fritz ;
Deltoro, Miguel Garcia ;
Swindells, Susan ;
Andrade-Villanueva, Jaime Federico ;
Wong, Alexander ;
Khuong-Josses, Marie-Aude ;
Van Solingen-Ristea, Rodica ;
van Eygen, Veerle ;
Crauwels, Herta ;
Ford, Susan ;
Talarico, Christine ;
Benn, Paul ;
Wang, Yuanyuan ;
Hudson, Krischan J. ;
Chounta, Vasiliki ;
Cutrell, Amy ;
Patel, Parul ;
Shaefer, Mark ;
Margolis, David A. ;
Smith, Kimberly Y. ;
Vanveggel, Simon ;
Spreen, William .
LANCET, 2020, 396 (10267) :1994-2005
[10]   Comparison of Adherence to Medications and to Clinic Visits between HIV Infected Adolescents and Young Adults: Perinatally versus Behaviorally Infected [J].
Reddy, S. ;
Seth, D. ;
Malhotra, G. ;
Zeballos-chavez, R. ;
Secord, E. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (02) :AB79-AB79