Polymorphisms of the adiponectin gene and their relationship with clinical-metabolic diseases: a narrative review

被引：0

作者：

Patricia Sanchez, Maria ^{[1
,2
,3
]}

Prieto Fuenmayor, Carem Francelys ^{[4
]}

Revilla Ramirez, Desiree Daniela ^{[4
]}

Castillo Solano, Freddy Damian ^{[4
]}

Cardona Vazquez, Maikell Eduardo ^{[1
,2
,3
]}

Beatriz Valera, Angelis ^{[1
,2
,3
]}

机构：

[1] Temple Univ Hosp & Med Sch, Nephrol, Philadelphia, PA USA

[2] Univ Zulia, Fac Med, Ctr Invest Endocrino Metab Dr Felix Gomez, Maracaibo, Venezuela

[3] Univ Zulia, Fac Med, Escuela Bioanal, Maracaibo, Venezuela

[4] Univ Catolica Cuenca, Cuenca, Ecuador

来源：

INVESTIGACION CLINICA | 2022年 / 63卷

关键词：

Adipokines; adiponectin; obesity; metabolic syndrome;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Adiponectin is a protein produced by the adipocyte in its differentiation, which exerts favorable metabolic effects such as increasing insulin sensitivity, inhibiting inflammation and atherogenesis. It is encoded by the ADIPOQ gene, whose 45 T > G, +276 G > T and 11,377 C > G polymorphisms have been associated with unfavorable metabolic events. Numerous studies have observed the role of these polymorphisms in the development of different clinical-metabolic diseases and this review is carried out with the aim of facilitating a better understanding of the genetic component of these disorders.

引用

页码：301 / 309

页数：9

共 47 条

[1]

Al-Awadi AM, 2022, REPROD BIOMED ONLINE, V45, P995, DOI [10.1016/j.rbmo.2022.06.0091472, 10.1016/j.rbmo.2022.06.009]

[2] Association of the ADIPOQ-AS LncRNA polymorphism rs2241766 with obesity: A Meta-analysis [J].

Ammar, M. N. ;

Lipovich, L. ;

Ali, R. M. ;

Amelina, M. A. ;

Shkurat, T. P. .

HUMAN GENE, 2022, 34

[3]

Bhat SA, 2018, Translational Metabolic Syndrome Research, V1, P39, DOI [10.1016/j.tmsr.2018.09.002, DOI 10.1016/J.TMSR.2018.09.002]

[4] Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot [J].

Cui, Meng ;

Gao, Yumin ;

Zhao, Yanping ;

Pang, Hui ;

Chen, Le ;

Wang, Zhidi ;

Zhao, Lingyan ;

Li, Minhui .

BIOMED RESEARCH INTERNATIONAL, 2020, 2020

[5] Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus [J].

Dong, Yuwei ;

Huang, Gongping ;

Wang, Xin ;

Chu, Zhaoming ;

Miao, Jingzhi ;

Zhou, Houwen .

PLOS ONE, 2020, 15 (10)

[6]

Elissondo N, 2008, ACTA BIOQUIM CLIN L, V42, P15

[7] G276T polymorphism in the ADIPOQ gene is associated with a reduced risk of polycystic ovarian syndrome: A meta-analysis of Asian population [J].

Enrique Tiongco, Raphael ;

Jowe Cabrera, Franzielle ;

Clemente, Benjie ;

Christopher Flake, Chastene ;

Angela Salunga, Micah ;

Ruth Pineda-Cortel, Maria .

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 2019, 58 (03) :409-416

[8] Associations between polymorphisms of the ADIPOQ gene and hypertension risk: a systematic and meta-analysis [J].

Fan, Weina ;

Qu, Xiaowei ;

Li, Jing ;

Wang, Xingning ;

Bai, Yanping ;

Cao, Qingmei ;

Ma, Liqun ;

Zhou, Xiaoyao ;

Zhu, Wei ;

Liu, Wei ;

Ma, Qiang .

SCIENTIFIC REPORTS, 2017, 7

[9] The adipocyte:: a model for integration of endocrine and metabolic signaling in energy metabolism regulation [J].

Frühbeck, G ;

Gómez-Ambrosi, J ;

Muruzábal, FJ ;

Burrell, MA .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2001, 280 (06) :E827-E847

[10] Adiponectin Signaling and Metabolic Syndrome [J].

Fu, Yuchang .

GLUCOSE HOMEOSTATIS AND THE PATHOGENESIS OF DIABETES MELLITUS, 2014, 121 :293-319

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