Endothelial cells modulate bone marrow fibrosis

被引：0

作者：

Schneider, Rebekka K. ^{[1
]}

Adams, Ralf H. ^{[2
]}

机构：

[1] Univ Hosp RWTH Aachen, Aachen, Germany

[2] Max Planck Inst Mol Biomed, Munster, Germany

来源：

NATURE CARDIOVASCULAR RESEARCH | 2024年 / 3卷 / 08期

关键词：

D O I：

10.1038/s44161-024-00521-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelial-cell-specific inactivation of Lats2 or overexpression of YAP1, which are components of the Hippo pathway, induces myofibroblast formation. This leads to extensive fibrosis, osteosclerosis and impaired bone marrow function, and such changes are mediated by endothelial-to-mesenchymal transition. These findings offer insights into potential therapeutic strategies for myelofibrosis and osteosclerosis.

引用

页码：895 / 896

页数：2

共 4 条

[1] Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis [J].