IGF-1 induces sex-specific oxidative damage and mortality in a songbird

被引:0
|
作者
Lendvai, adam Z. [1 ]
Toth, Zsofia [1 ,2 ,6 ]
Mahr, Katharina [3 ]
Penzes, Janka [4 ]
Vogel-Kindgen, Sarah [5 ]
Gander, Bruno A. [5 ]
Vagasi, Csongor I. [1 ,4 ]
机构
[1] Univ Debrecen, Dept Evolutionary Zool & Human Biol, Debrecen, Hungary
[2] Univ Debrecen, Pal Juhasz Nagy Doctoral Sch Biol Environm Sci, Debrecen, Hungary
[3] Univ Vet Med, Konrad Lorenz Inst Ethol, Dept Interdisciplinary Life Sci, Vienna, Austria
[4] Babes Bolyai Univ, Hungarian Dept Biol & Ecol, Evolutionary Ecol Grp, Cluj Napoca, Romania
[5] Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland
[6] Lund Univ, Dept Biol, Lund, Sweden
基金
奥地利科学基金会;
关键词
IGF-1; Oxidative stress; Lifespan; Fitness; Somatotropic axis; GROWTH-FACTOR; 1; LIFE-SPAN; STRESS; LONGEVITY; INSULIN/IGF-1; MECHANISMS; RESISTANCE; SYSTEM;
D O I
10.1007/s00442-024-05587-y
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
The insulin-like growth factor 1 (IGF-1) is a pleiotropic hormone that regulates essential life-history traits and is known for its major contribution to determining individual ageing processes. High levels of IGF-1 have been linked to increased mortality and are hypothesised to cause oxidative stress. This effect has been observed in laboratory animals, but whether it pertains to wild vertebrates has not been tested. This is surprising because studying the mechanisms that shape individual differences in lifespan is important to understanding mortality patterns in populations of free-living animals. We tested this hypothesis under semi-natural conditions by simulating elevated IGF-1 levels in captive bearded reedlings, a songbird species with an exceptionally fast pace of life. We subcutaneously injected slow-release biodegradable microspheres loaded with IGF-1 and achieved a systemic 3.7-fold increase of the hormone within the natural range for at least 24 h. Oxidative damage to lipids showed marked sexual differences: it significantly increased the day after the manipulation in treated males and returned to baseline levels four days post-treatment, while no treatment effect was apparent in females. Although there was no overall difference in survival between the treatment groups, high initial (pre-treatment) IGF-1 and low post-treatment plasma malondialdehyde levels were associated with enhanced survival prospects in males. These results suggest that males may be more susceptible to IGF-1-induced oxidative stress than females and quickly restoring oxidative balance may be related to fitness. IGF-1 levels evolve under opposing selection forces, and natural variation in this hormone's level may reflect the outcome of individual optimization.
引用
收藏
页码:561 / 570
页数:10
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