Anionic nanoparticle-lipid membrane interactions: the protonation of anionic ligands at the membrane surface reduces membrane disruption

被引：20

作者：

Salassi, Sebastian ^{[1
]}

Canepa, Ester ^{[2
]}

Ferrando, Riccardo ^{[1
]}

Rossi, Giulia ^{[1
]}

机构：

[1] Univ Genoa, Dept Phys, Via Dodecaneso 33, I-16146 Genoa, Italy

[2] Univ Genoa, Dept Chem & Ind Chem, Via Dodecaneso 31, I-16146 Genoa, Italy

来源：

RSC ADVANCES | 2019年 / 9卷 / 25期

关键词：

GOLD NANOPARTICLES; MOLECULAR-DYNAMICS; AU NANOPARTICLES; AMINO-ACIDS; INSERTION; MODEL;

D O I：

10.1039/c9ra02462j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monolayer-protected gold nanoparticles (Au NPs) are promising biomedical tools with applications in diagnosis and therapy, thanks to their biocompatibility and versatility. Here we show how the NP surface functionalization can drive the mechanism of interaction with lipid membranes. In particular, we show that the spontaneous protonation of anionic carboxylic groups on the NP surface can make the NP-membrane interaction faster and less disruptive.

引用

页码：13992 / 13997

页数：6

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