TBAI-Catalyzed, TBHP-Mediated Modular Three-Component Cascade Towards Highly Functionalized Pyrrole via [3+2] Annulation

被引：0

作者：

Gnanaoli, Karthiyayini ^{[1
]}

Rajkumar, Deepan Babu ^{[1
]}

Gopal, Keerthana ^{[1
]}

Saritha, B. ^{[1
]}

Maheswari, C. Uma ^{[1
]}

机构：

[1] SASTRA Deemed Univ, Sch Chem & Biotechnol, Dept Chem, Thanjavur 613401, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 20期

关键词：

Pyrrole; Iodine; Multi-component reaction; Annulation; N-heterocycle; DERIVATIVES; DIMERIZATION; CYCLIZATION;

D O I：

10.1002/ejoc.202400197

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile, one-pot sequential synthesis of highly substituted pyrrole employing TBAI/TBHP has been developed from readily available precursors. beta-Enaminones generated in situ from beta-ketoesters and primary amines react sequentially with electron-deficient alkynes via a radical pathway to form the penta-substituted pyrroles in moderate to good yields. This strategy for the synthesis of highly functionalized pyrroles can be scaled up and shows tolerance to a variety of amines.

引用

页数：6

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