Testicular Seminoma in Prostate: Case Report and Review of Literature

center dot This case report points out, unusual case of man with testicular cancer who experienced late relapse in unusual site of metastasis or another sequential primary extragonadal tumor in prostate (PEGCT). Case report also includes described cases available in literature and reviewed separately for PEGCT and for metastasis of germ cell tumor to prostate. Solitary unusual site of late relapse to prostate represents very rare entity, however we speculate, that mechanism of seeding in prostate might be caused by redirected blood flow, moreover, on the other hand, presence of seminoma in prostate could be caused by another primary germ cell tumor in prostate as well. center dot Our finding suggests, that in our peculiar case and similar clinical scenarios is essential to think about another primary extragonadal tumor (PEGCT). Unfortunately, whether, appropriate treatment approach should be driven according to IGCCG cr iter ia staged as intermediate-risk disease (in case of metastasis) or to good risk disease (in case that we suspect PEGCT) is up for debate. However, we incline to 4 cycles of VIP or BEP chemotherapy staged as intermediate-risk disease. Speculations about surgery were accompanied by lack of data and extrapolations from stage I relapses are only speculations. center dot This case report impacts future by adding knowledge value to similar cases in terms of considering adequate treatment approach according to internal recommendations such as NCCN or ESMO. However, question about primary origin of tumor in terms of, whether, it is late recurrence or PEGCT in similar clinical scenarios will mostly remain unresolved. Thus, in similar case scenario treatment approach as intermediate- risk disease should be standard of care according to international guidelines.