Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury

被引：123
作者：
Zhao W.-K. [1 ]
Zhou Y. [2 ,3 ]
Xu T.-T. [1 ]
Wu Q. [4 ]
机构：
[1] Department of Health Care Ward, First Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin
[2] Department of Pathophysiology, Xuzhou Medical University, Jiangsu province, Xuzhou
[3] Laboratory of Clinical and Experimental Pathology, Xuzhou Medical University, Jiangsu province, Xuzhou
[4] Department of Physiology, Xuzhou Medical University, Jiangsu province, Xuzhou
来源：
Oxidative Medicine and Cellular Longevity | 2021年 / 2021卷
基金：
中国国家自然科学基金;
关键词：
Oxidative stress - Lipids - Oxidation;
D O I：
10.1155/2021/9929687
中图分类号：
学科分类号：
摘要：
Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane lipid peroxidation due to redox imbalances and excessive ROS accumulation, damaging the integrity of cell membranes. Ferroptosis is mainly characterized by mitochondrial shrinkage, increased density of bilayer membranes, and the accumulation of lipid peroxidation. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable risk event for acute myocardial infarction. Ferroptosis is closely associated with MIRI, and this relationship is discussed in detail here. This review systematically summarizes the process of ferroptosis and the latest research progress on the role of ferroptosis in MIRI to provide new ideas for the prevention and treatment of MIRI. © 2021 Wei-kun Zhao et al.
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共 99 条
[1]  
Tang D., Chen X., Kang R., Kroemer G., Ferroptosis: Molecular mechanisms and health implications, Cell Research, 31, 2, pp. 107-125, (2021)
[2]  
Yu H.T., Guo P.Y., Xie X.Z., Wang Y., Chen G., Ferroptosis, a new form of cell death, and its relationships with tumourous diseases, Journal of Cellular & Molecular Medicine, 21, 4, pp. 648-657, (2017)
[3]  
Zeng J., Chen Y., Xu X., Research progress of ferroptosis-related mechanisms, regulation and diseases, Chinese Pharmaceutical Journal, 52, 4, pp. 253-257, (2017)
[4]  
Angeli J.P.F., Shah R., Pratt D.A., Conrad M., Ferroptosis inhibition: Mechanisms and opportunities, Trends in Pharmacological Sciences, 38, 5, pp. 489-498, (2017)
[5]  
Lillo-Moya J., Rojas-Sole C., Munoz-Salamanca D., Panieri E., Saso L., Rodrigo R., Targeting ferroptosis against ischemia/reperfusion cardiac injury, Antioxidants (Basel), 10, 5, (2021)
[6]  
Baba Y., Higa J.K., Shimada B.K., Horiuchi K.M., Suhara T., Kobayashi M., Woo J.D., Aoyagi H., Marh K.S., Kitaoka H., Matsui T., Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes, American Journal of Physiology. Heart and Circulatory Physiology, 314, 3, pp. H659-H668, (2018)
[7]  
Gao M., Monian P., Quadri N., Ramasamy R., Jiang X., Glutaminolysis and transferrin regulate ferroptosis, Molecular Cell, 59, 2, pp. 298-308, (2015)
[8]  
Dixon S.J., Lemberg K.M., Lamprecht M.R., Skouta R., Zaitsev E.M., Gleason C.E., Patel D.N., Bauer A.J., Cantley A.M., Yang W.S., Morrison Iii. B., Stockwell B.R., Ferroptosis: An iron-dependent form of nonapoptotic cell death, Cell, 149, 5, pp. 1060-1072, (2012)
[9]  
Dolma S., Lessnick S.L., Hahn W.C., Stockwell B.R., Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells, Cancer Cell, 3, 3, pp. 285-296, (2003)
[10]  
Yang W.S., Stockwell B.R., Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, Chemistry & Biology, 15, 3, pp. 234-245, (2008)
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