Effects of angiotensin receptor-neprilysin inhibitor on ketone body metabolism in pre-heart failure/heart failure patients

被引:0
作者
Kashiwagi, Yusuke [1 ]
Nagoshi, Tomohisa [1 ]
Tanaka, Yoshiro [1 ]
Oi, Yuhei [1 ]
Kimura, Haruka [1 ]
Ogawa, Kazuo [1 ]
Kawai, Makoto [1 ]
Yoshimura, Michihiro [1 ]
机构
[1] Jikei Univ, Sch Med, Dept Internal Med, Div Cardiol, 3-25-8 Nishi Shimbashi,Minato Ku, Tokyo 1058461, Japan
关键词
Angiotensin receptor-neprilysin inhibitor (ARNI); Ketone body; Heart failure; PPAR-ALPHA; NATRIURETIC PEPTIDES; LIPID-METABOLISM; BODIES; ENALAPRIL; IMPACT; MOUSE;
D O I
10.1038/s41598-024-67524-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recently, a mild elevation of the blood ketone levels was found to exert multifaceted cardioprotective effects. To investigate the effect of angiotensin receptor neprilysin inhibitors (ARNIs) on the blood ketone body levels, 46 stable pre-heart failure (HF)/HF patients were studied, including 23 who switched from angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) to ARNIs (ARNI group) and 23 who continued treatment with ACE inhibitors or ARBs (control group). At baseline, there were no significant differences in the total ketone body (TKB) levels between the two groups. Three months later, the TKB levels in the ARNI group were higher than the baseline values (baseline to 3 months: 71 [51, 122] to 92 [61, 270] mu mol/L, P < 0.01). In the control group, no significant change was observed between the baseline and 3 months later. A multiple regression analysis demonstrated that the initiation of ARNI and an increase in the blood non-esterified fatty acid (NEFA) levels at 3 months increased the percentage changes in the TKB levels from baseline to 3 months (%Delta TKB level) (initiation of ARNI: P = 0.017, NEFA level at 3 months: P < 0.001). These results indicate that ARNI administration induces a mild elevation of the blood TKB levels in pre-HF/HF patients.
引用
收藏
页数:9
相关论文
共 37 条
[2]   Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation [J].
Arima, Yuichiro ;
Nakagawa, Yoshiko ;
Takeo, Toru ;
Ishida, Toshifumi ;
Yamada, Toshihiro ;
Hino, Shinjiro ;
Nakao, Mitsuyoshi ;
Hanada, Sanshiro ;
Umemoto, Terumasa ;
Suda, Toshio ;
Sakuma, Tetsushi ;
Yamamoto, Takashi ;
Watanabe, Takehisa ;
Nagaoka, Katsuya ;
Tanaka, Yasuhito ;
Kawamura, Yumiko K. ;
Tonami, Kazuo ;
Kurihara, Hiroki ;
Sato, Yoshifumi ;
Yamagata, Kazuya ;
Nakamura, Taishi ;
Araki, Satoshi ;
Yamamoto, Eiichiro ;
Izumiya, Yasuhiro ;
Sakamoto, Kenji ;
Kaikita, Koichi ;
Matsushita, Kenichi ;
Nishiyama, Koichi ;
Nakagata, Naomi ;
Tsujita, Kenichi .
NATURE METABOLISM, 2021, 3 (02) :196-+
[3]   The Failing Heart Relies on Ketone Bodies as a Fuel [J].
Aubert, Gregory ;
Martin, Ola J. ;
Horton, Julie L. ;
Lai, Ling ;
Vega, Rick B. ;
Leone, Teresa C. ;
Koves, Timothy ;
Gardell, Stephen J. ;
Krueger, Marcus ;
Hoppel, Charles L. ;
Lewandowski, E. Douglas ;
Crawford, Peter A. ;
Muoio, Deborah M. ;
Kelly, Daniel P. .
CIRCULATION, 2016, 133 (08) :698-705
[4]  
Badman MK, 2007, CELL METAB, V5, P426, DOI 10.1016/j.cmet.2007.05.002
[5]   Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure [J].
Bedi, Kenneth C., Jr. ;
Snyder, Nathaniel W. ;
Brandimarto, Jeffrey ;
Aziz, Moez ;
Mesaros, Clementina ;
Worth, Andrew J. ;
Wang, Linda L. ;
Javaheri, Ali ;
Blair, Ian A. ;
Margulies, Kenneth B. ;
Rame, J. Eduardo .
CIRCULATION, 2016, 133 (08) :706-716
[6]   Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes [J].
Bordicchia, Marica ;
Liu, Dianxin ;
Amri, Ez-Zoubir ;
Ailhaud, Gerard ;
Dessi-Fulgheri, Paolo ;
Zhang, Chaoying ;
Takahashi, Nobuyuki ;
Sarzani, Riccardo ;
Collins, Sheila .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (03) :1022-1036
[7]   Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis [J].
Carper, Deborah ;
Coue, Marine ;
Nascimento, Emmani B. M. ;
Barquissau, Valentin ;
Lagarde, Damien ;
Pestourie, Carine ;
Laurens, Claire ;
Petit, Justine Vily ;
Soty, Maud ;
Monbrun, Laurent ;
Marques, Marie-Adeline ;
Jeanson, Yannick ;
Sainte-Marie, Yannis ;
Mairal, Aline ;
Dejean, Sebastien ;
Tavernier, Genevieve ;
Viguerie, Nathalie ;
Bourlier, Virginie ;
Lezoualc'h, Frank ;
Carriere, Audrey ;
Saris, Wim H. M. ;
Astrup, Arne ;
Casteilla, Louis ;
Mithieux, Gilles ;
Lichtenbelt, Wouter van Marken ;
Langin, Dominique ;
Schrauwen, Patrick ;
Moro, Cedric .
CELL REPORTS, 2020, 32 (08)
[8]   Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF [J].
Deng, Yan ;
Xie, Maodi ;
Li, Qian ;
Xu, Xuewen ;
Ou, Wei ;
Zhang, Yabing ;
Xiao, Haitao ;
Yu, Hai ;
Zheng, Yanyi ;
Liang, Yu ;
Jiang, Chunling ;
Chen, Guo ;
Du, Dan ;
Zheng, Wen ;
Wang, Shisheng ;
Gong, Meng ;
Chen, Yaohui ;
Tian, Rong ;
Li, Tao .
CIRCULATION RESEARCH, 2021, 128 (02) :232-245
[9]   Metabolic Impairment in Heart Failure The Myocardial and Systemic Perspective [J].
Doehner, Wolfram .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (13) :1389-1400
[10]   CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis [J].
Ferrannini, Ele ;
Mark, Michael ;
Mayoux, Eric .
DIABETES CARE, 2016, 39 (07) :1108-1114